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Effects of ranolazine on cardiac function in rats with heart failure.

Author: HeX-N, LiH, WangG-T, YuZ-Q

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Ranolazine improved cardiac function and inhibited myocardial apoptosis in rats with chronic heart failure (CHF), which could be attributed to the regulation of AKT phosphorylation. The drug significantly reduced left ventricular end-diastolic pressure and increased the maximal rate of left ventricular pressure rise and fall.
Paper Details　
Original Abstract of the Article :
OBJECTIVE: To investigate the effects of ranolazine on the cardiac function and myocardial apoptosis in rats with heart failure and its possible mechanisms. MATERIALS AND METHODS: Thirty Wistar rats were randomly divided into sham operation (negative control; NC), chronic heart failure (CHF), and r...See full text at original site
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引用元：
https://doi.org/10.26355/eurrev_201911_19456

データ提供：米国国立医学図書館（NLM）

Ranolazine: A New Oasis in the Desert of Heart Failure

Heart failure, a debilitating condition that weakens the heart's ability to pump blood effectively, is like a harsh desert environment, leaving patients feeling drained and struggling to cope. This study investigates the effects of ranolazine, a drug used to treat angina, on cardiac function in rats with heart failure. It's like bringing a refreshing oasis to the heart of this challenging condition.

The researchers found that ranolazine improved cardiac function and inhibited myocardial apoptosis in rats with heart failure. This was achieved through the regulation of AKT phosphorylation, a critical signaling pathway involved in cell survival and growth. Their findings suggest that ranolazine may offer a potential therapeutic benefit for patients with heart failure.

Navigating the Desert of Heart Failure: Finding Hope

This research offers a glimmer of hope in the desert of heart failure. It suggests that ranolazine may have a role in managing the condition and improving patient outcomes.

The Oasis of Research: Unlocking New Treatments

This study underscores the importance of ongoing research in finding new and effective treatments for heart failure. By exploring different therapeutic approaches and understanding the underlying mechanisms of the disease, researchers continue to make significant strides in improving patient care.

Dr. Camel's Conclusion

Ranolazine emerges as a potential oasis in the desert of heart failure. Its ability to improve cardiac function and inhibit myocardial apoptosis offers a glimmer of hope for patients struggling with this debilitating condition.

Date :
  1. Date Completed 2020-12-14
  2. Date Revised 2020-12-14
Further Info :

Pubmed ID

31773713

DOI: Digital Object Identifier

10.26355/eurrev_201911_19456

Related Literature

Article Analysis
・Effects of ranolazine
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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