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Selective Effects of Thioridazine on Self-Renewal of Basal-Like Breast Cancer Cells.
Author: BaldwinAlbert S, FanCheng, TegowskiMatthew
Original Abstract of the Article :
Several recent publications demonstrated that DRD2-targeting antipsychotics such as thioridazine induce proliferation arrest and apoptosis in diverse cancer cell types including those derived from brain, lung, colon, and breast. While most studies show that 10-20 µM thioridazine leads to reduced pro...See full text at original site
Dr.Camel's Paper Summary Blogラクダ博士について
ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。
* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。
引用元:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6904738/
データ提供:米国国立医学図書館(NLM)
Targeting the Self-Renewal of Basal-Like Breast Cancer Cells
This study focuses on the promising area of cancer research, specifically exploring the potential of thioridazine, an antipsychotic drug, to inhibit the self-renewal of basal-like breast cancer cells. The researchers discovered that low doses of thioridazine effectively targeted the self-renewal of these cells, but not other subtypes of breast cancer cells. This finding suggests that thioridazine might be a potential treatment for basal-like breast cancer. The study also found that dopamine, a neurotransmitter, can be detected in breast tumor samples, suggesting that dopamine receptors may be activated in these cancers. This discovery could lead to further investigation of dopamine receptors as therapeutic targets for breast cancer.
A Potential New Weapon in the Fight Against Breast Cancer
This study suggests that thioridazine could be a valuable tool in the fight against basal-like breast cancer. By targeting the self-renewal of these cancer cells, thioridazine may be able to slow down tumor growth and improve patient outcomes. The finding that dopamine can be detected in breast tumors opens up a new avenue for research, potentially leading to the development of targeted therapies that exploit the role of dopamine in breast cancer development.
Beyond the Sand Dunes: The Importance of Personalized Cancer Treatment
Cancer treatment is a challenging journey. This research highlights the importance of personalized medicine, where treatments are tailored to the specific type and characteristics of the cancer. Understanding the unique biological features of different cancer subtypes, such as basal-like breast cancer, is crucial for developing effective and targeted therapies. The discovery of dopamine's role in breast cancer could pave the way for novel treatment approaches that are more effective and less toxic for patients. This is a journey we must all embark on to defeat this formidable adversary.
Dr. Camel's Conclusion
This study offers hope in the battle against breast cancer, demonstrating that thioridazine, a commonly used antipsychotic medication, may hold potential for treating basal-like breast cancer. This discovery underscores the importance of investigating existing medications for their potential applications in treating cancer. This is a crucial step in the ongoing quest to find effective and personalized treatments for this challenging disease.
Date :
- Date Completed 2020-11-23
- Date Revised 2021-01-10
Further Info :
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