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Identify old drugs as selective bacterial β-GUS inhibitors by structural-based virtual screening and bio-evaluations.
Author: ChangShan, ChenZhou, KongRen, LiuJiyong, PiaoLianhua, XuXiaoshuang
Original Abstract of the Article :
Irinotecan (CPT-11) is a cytotoxic drug that has wide applicability and usage in cancer treatment. Despite its success, patients suffer dose-dependent diarrhea, limiting the drug's efficacy. No effective therapy is available for this unmet medical need. The bacterial β-glucuronidase (β-GUS...See full text at original site
Dr.Camel's Paper Summary Blogラクダ博士について
ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。
* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。
引用元:
https://doi.org/10.1111/cbdd.13655
データ提供:米国国立医学図書館(NLM)
Old Drugs, New Hope for Bacterial β-GUS Inhibition
The world of [bacterial infections] is a challenging one, often characterized by the search for new and effective treatments. This research explores the potential of repurposing existing drugs to combat [bacterial β-GUS], an enzyme that plays a role in the development of [diarrhea] associated with certain medications. Researchers, like alchemists searching for hidden treasures in a vast desert of pharmaceutical possibilities, are seeking new ways to harness the power of existing drugs to address unmet medical needs.
A New Life for Old Drugs
The study identified several existing drugs, including [N-Desmethylclozapine, Aspartame, and Gemifloxacin], that exhibited potent inhibitory activity against [bacterial β-GUS]. The researchers found that these drugs were highly effective in blocking the activity of [bacterial β-GUS] both in lab settings and in live bacteria.
A New Frontier in Drug Repurposing
This research opens up exciting new possibilities in the field of [drug repurposing]. By identifying new uses for existing drugs, researchers can accelerate the development of new treatments and improve the lives of patients. The study suggests that repurposing existing drugs could be a valuable strategy for addressing the challenge of [bacterial infections] and other unmet medical needs.
Dr.Camel's Conclusion
This research highlights the potential of repurposing existing drugs to combat [bacterial β-GUS], a promising strategy for developing new treatments to address the challenge of bacterial infections. It's a reminder that even in the vast desert of pharmaceutical possibilities, new hope and solutions can be found.
Date :
- Date Completed 2021-05-18
- Date Revised 2021-05-18
Further Info :
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