Identify old drugs as selective bacterial β-GUS inhibitors by structural-based virtual screening and bio-evaluations.

Author: ChangShan, ChenZhou, KongRen, LiuJiyong, PiaoLianhua, XuXiaoshuang

Paper Details 
Original Abstract of the Article :
Irinotecan (CPT-11) is a cytotoxic drug that has wide applicability and usage in cancer treatment. Despite its success, patients suffer dose-dependent diarrhea, limiting the drug's efficacy. No effective therapy is available for this unmet medical need. The bacterial β-glucuronidase (β-GUS...See full text at original site
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引用元:
https://doi.org/10.1111/cbdd.13655

データ提供:米国国立医学図書館(NLM)

Old Drugs, New Hope for Bacterial β-GUS Inhibition

The world of [bacterial infections] is a challenging one, often characterized by the search for new and effective treatments. This research explores the potential of repurposing existing drugs to combat [bacterial β-GUS], an enzyme that plays a role in the development of [diarrhea] associated with certain medications. Researchers, like alchemists searching for hidden treasures in a vast desert of pharmaceutical possibilities, are seeking new ways to harness the power of existing drugs to address unmet medical needs.

A New Life for Old Drugs

The study identified several existing drugs, including [N-Desmethylclozapine, Aspartame, and Gemifloxacin], that exhibited potent inhibitory activity against [bacterial β-GUS]. The researchers found that these drugs were highly effective in blocking the activity of [bacterial β-GUS] both in lab settings and in live bacteria.

A New Frontier in Drug Repurposing

This research opens up exciting new possibilities in the field of [drug repurposing]. By identifying new uses for existing drugs, researchers can accelerate the development of new treatments and improve the lives of patients. The study suggests that repurposing existing drugs could be a valuable strategy for addressing the challenge of [bacterial infections] and other unmet medical needs.

Dr.Camel's Conclusion

This research highlights the potential of repurposing existing drugs to combat [bacterial β-GUS], a promising strategy for developing new treatments to address the challenge of bacterial infections. It's a reminder that even in the vast desert of pharmaceutical possibilities, new hope and solutions can be found.

Date :
  1. Date Completed 2021-05-18
  2. Date Revised 2021-05-18
Further Info :

Pubmed ID

31834987

DOI: Digital Object Identifier

10.1111/cbdd.13655

Related Literature

SNS
PICO Info
in preparation
Languages

English

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