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Selected pharmacotherapy agents as antiproliferative and anti-inflammatory compounds.

Author: Al-HiariYusuf, Al-ZweiriMuhammad, AlKhalilMthanna, ArabiyatShereen, KasabriViolet, MamdoohNoor, TelfahAhmad

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study investigated the potential of acidic chelator drugs as anti-cancer agents. The 15 selected drugs from eight classes showed anti-proliferative activity against certain cancer cell lines. Notably, atorvastatin showed significant cytotoxicity against A375.2S cells, comparable to cisplatin, while levofloxacin and ciprofloxacin demonstrated superior activity against the K562 cell line. The study highlights the potential of acidic chelator drugs for repurposing in cancer chemotherapy and prevention.
Paper Details　
Original Abstract of the Article :
The repurposing of safe therapeutic drugs has emerged as an alternative approach to rapidly identify effective, safe, and conveniently available therapeutics to treat/prevent cancer. Therefore, it was hypothesized that acidic chelator drugs could have a genuine potential as antiproliferative agents....See full text at original site
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引用元：
https://doi.org/10.1002/ddr.21640

データ提供：米国国立医学図書館（NLM）

Repurposing Drugs: A New Oasis in the Desert of Cancer Treatment

The search for effective and safe cancer treatments is an ongoing pursuit. This study explores the potential of [drug repurposing] as a strategy to identify new therapeutic agents. The researchers focused on [acidic chelator drugs], a class of medications already used for various medical conditions. They investigated the anticancer activity of these drugs against a panel of cancer cell lines, discovering that several agents, including atorvastatin, gemifloxacin, and lansoprazole, exhibited significant antiproliferative and anti-inflammatory properties. These findings suggest that drug repurposing may offer a promising avenue for developing new cancer treatments.

Repurposing Drugs: A New Horizon in Cancer Therapy

This study provides a compelling argument for the potential of drug repurposing in cancer treatment. The discovery that acidic chelator drugs exhibit anticancer properties suggests that these existing medications may offer valuable therapeutic options for various cancers. The study also highlights the importance of exploring existing drugs for new applications, potentially leading to the development of more effective and safe cancer treatments.

Navigating the Complexities of Cancer Treatment

This study underscores the need for innovative approaches to cancer treatment. Repurposing existing drugs offers a promising avenue for developing new therapies, potentially leading to faster development times and greater affordability. The study's findings encourage further research into the repurposing of existing drugs for various diseases, including cancer.

Dr.Camel's Conclusion

Just as a camel adapts to the diverse landscapes of the desert, drug repurposing allows us to adapt existing medications to new challenges. This study demonstrates the potential of this approach in developing new cancer treatments, offering hope for a more effective and personalized approach to battling this complex disease.

Date :
  1. Date Completed 2021-08-02
  2. Date Revised 2021-08-02
Further Info :

Pubmed ID

31943302

DOI: Digital Object Identifier

10.1002/ddr.21640

Related Literature

Article Analysis
・Effects of gemifloxacin
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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