Pharmacokinetic and pharmacodynamic of the cognitive enhancer modafinil: Relevant clinical and forensic aspects.

Author: Dinis-OliveiraRicardo Jorge, SousaAna

Paper Details 
Original Abstract of the Article :
Modafinil is a nonamphetamine nootropic drug with an increasingly therapeutic interest due to its different sites of action and behavioral effects in comparison to cocaine or amphetamine. A review of modafinil (and of its prodrug adrafinil and its <i>R</i>-enantiomer armodafinil) chemical, pharmacok...See full text at original site
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引用元:
https://doi.org/10.1080/08897077.2019.1700584

データ提供:米国国立医学図書館(NLM)

Modafinil: A Cognitive Enhancer with Complex Effects

Modafinil, a non-amphetamine nootropic drug, has gained considerable attention for its unique cognitive effects and potential therapeutic benefits. This review delves into the intricate pharmacological and pharmacokinetic properties of modafinil, exploring its diverse mechanisms of action and its role in various clinical and forensic contexts.

Unveiling the Mechanisms of Modafinil

The study reveals that modafinil's effects likely stem from its inhibition of dopamine reuptake and its modulation of various neurochemical pathways, including those involving noradrenaline, serotonin, orexin, histamine, glutamate, and GABA. The study highlights the potential benefits of modafinil for treating conditions associated with sleepiness, fatigue, and cognitive impairment. However, it also acknowledges the need for further research to better understand its potential risks and implications for health.

Navigating the Complexities of Modafinil

The use of modafinil in various clinical settings, including the treatment of narcolepsy and shift work sleep disorder, presents a unique challenge. Like a desert traveler seeking an oasis, we must navigate the complexities of this drug's effects carefully. While it holds promise for improving cognitive function and combating sleepiness, potential adverse effects such as headaches, insomnia, and anxiety must be considered.

Dr.Camel's Conclusion

Modafinil, with its complex mechanisms of action and potential for both benefits and risks, stands as a fascinating subject in the vast desert of pharmacological research. While it offers hope for those seeking to improve their cognitive function and overcome sleepiness, its use should be carefully considered and monitored to avoid potential negative consequences.

Date :
  1. Date Completed 2021-09-21
  2. Date Revised 2021-09-21
Further Info :

Pubmed ID

31951804

DOI: Digital Object Identifier

10.1080/08897077.2019.1700584

Related Literature

SNS
PICO Info
in preparation
Languages

English

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