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Cloned <i>ermTR</i> Gene Confers Low Level Erythromycin but High Level Clindamycin Resistance in <i>Streptococcus pyogenes</i> NZ131.

Author: BozdoğanBülent, BıyıkHacı Halil, OryaşınErman, TristramStephen

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

This study investigated the effects of the ermTR gene, a common mechanism of macrolide resistance in streptococci, on the activity of macrolides and lincosamides. The study found that ermTR conferred low-level resistance to erythromycin and high-level resistance to clindamycin. The induction and resistance profiles of ermTR differed from other erm genes, suggesting that the methylation of ErmTR may be distinct.
Paper Details　
Original Abstract of the Article :
<b><i>Objectives:</i></b> The most common macrolide resistance mechanisms in streptococci are the presence of methylase encoding genes <i>ermB</i> and <i>ermTR</i> or the presence of efflux encoded by <i>mef</i> genes. In the present study we aimed to show the effects of the <i>ermTR</i> gene under...See full text at original site
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引用元：
https://doi.org/10.1089/mdr.2019.0133

データ提供：米国国立医学図書館（NLM）

The Cloned ermTR Gene: A Tale of Resistance

In the vast landscape of bacteria, antibiotic resistance is a constant battle. Just like a nomad tribe defending its territory, bacteria constantly evolve to outsmart the antibiotics we use to fight them. This study focuses on Streptococcus pyogenes, a common bacteria that can cause infections like strep throat. The researchers investigated the role of the ermTR gene, which can confer resistance to certain antibiotics, namely macrolides and lincosamides.

ermTR and Antibiotic Resistance

The study showed that the presence of the ermTR gene significantly increased resistance to clindamycin, a lincosamide antibiotic. It's like a camel developing a natural immunity to a desert plant that is toxic to other creatures. However, the resistance to erythromycin, a macrolide antibiotic, was only moderate. This suggests that the ermTR gene can provide different levels of resistance to different types of antibiotics, depending on the type of antibiotic and the presence of regulatory regions.

Implications for Treatment

The findings of this study are significant because they highlight the importance of understanding the specific mechanisms of antibiotic resistance. Just as a camel learns to navigate the different terrains of the desert, we need to develop new strategies to combat the growing threat of antibiotic resistance. It's imperative to stay one step ahead of the game.

Dr. Camel's Conclusion

This study delves into the intriguing world of antibiotic resistance. It highlights the intricate dance between bacteria and antibiotics, where each side constantly adapts and evolves. This research is essential for developing new antibiotics and strategies to combat the ever-growing challenge of antibiotic resistance.
Date :
  1. Date Completed 2021-05-05
  2. Date Revised 2021-05-05
Further Info :

Pubmed ID

31971866

DOI: Digital Object Identifier

10.1089/mdr.2019.0133

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Languages

English

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