Effects of lorcaserin on oxycodone self-administration and subjective responses in participants with opioid use disorder.

Author: BrandtLaura, ComerSandra D, JonesJermaine D, LevinFrances R, ManubayJeanne M, MartinezSuky, MogaliShanthi, RameyTatiana

Paper Details 
Original Abstract of the Article :
Label="BACKGROUND">Lorcaserin, a high-affinity 5-HT<sub>2C</sub> receptor agonist approved for treating obesity, decreased self-administration of oxycodone and cue-induced reinstatement of drug-seeking behavior in preclinical studies. The current investigation is the first clinical trial to evaluate...See full text at original site
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引用元:
https://pubmed.ncbi.nlm.nih.gov/31980285

データ提供:米国国立医学図書館(NLM)

Lorcaserin: A Potential Treatment for Opioid Use Disorder

This study delves into the potential of lorcaserin, a medication approved for treating obesity, as a treatment for opioid use disorder. The researchers conducted a clinical trial to evaluate lorcaserin's impact on the reinforcing and subjective effects of oxycodone, a common opioid. The study found that lorcaserin decreased self-administration of oxycodone and potentially reduced the urge to seek the drug. This study is the first to evaluate lorcaserin's effects in humans, paving the way for further research into its potential as a treatment for opioid use disorder.

Hope for Opioid Addiction

This study sheds light on the potential of lorcaserin in addressing opioid use disorder. The findings, while preliminary, suggest that lorcaserin could offer a new avenue for treatment, particularly by reducing the reinforcing effects of opioids. Further research is crucial to confirm these findings and explore the potential therapeutic applications of lorcaserin in managing opioid addiction.

Fighting Addiction: A Camel's Perspective on Finding Oasis

As a camel, I've learned to navigate the desert's harsh conditions, including its mirages. Addiction, much like a mirage, can be a deceptive and dangerous path. This research offers a glimmer of hope in the fight against opioid addiction, suggesting that lorcaserin could be a valuable tool for finding a path to recovery.

Dr.Camel's Conclusion

This study suggests that lorcaserin, a medication already approved for weight management, may have potential as a treatment for opioid use disorder. While further research is needed, it offers a promising avenue for addressing this complex public health issue.
Date :
  1. Date Completed 2021-01-18
  2. Date Revised 2023-03-03
Further Info :

Pubmed ID

31980285

DOI: Digital Object Identifier

NIHMS1550131

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Languages

English

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