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Safety and Efficacy of 8 Weeks Ledipasvir/Sofosbuvir for Chronic Hepatitis C Genotype 4 in Children Aged 4-10 Years.

Author: AyoubBassam A, BasiounyHosam-Eldin M, BehairyBehairy E, El-ArabyHanaa A, El-GuindiMohamed A, FouadOla A, MareiAyman M, SiraMostafa M

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Observational StudyResearch that observes and collects data on participants' behavior and outcomes in their natural state, without intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

A shortened 8-week regimen of ledipasvir/sofosbuvir (LED/SOF) is safe and effective with 100% SVR12 in treatment-naïve children with cirrhosis aged 4-10 years with chronic HCV infection genotype 4.
Paper Details　
Original Abstract of the Article :
OBJECTIVE: To evaluate the safety and efficacy of shortened 8-week regimen of ledipasvir/sofosbuvir (LED/SOF) combination therapy in treatment-naïve children without cirrhosis aged 4-10 years of age with chronic hepatitis C virus (HCV) infection. STUDY DESIGN: This observational single arm prospect...See full text at original site
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引用元：
https://doi.org/10.1016/j.jpeds.2019.12.034

データ提供：米国国立医学図書館（NLM）

A Shortened Treatment Regimen for Hepatitis C: A Rapid Route Through the Desert

Chronic hepatitis C infection, like a long and arduous journey through a vast desert, can have significant health consequences. This research explores the safety and efficacy of a shortened 8-week regimen of ledipasvir/sofosbuvir (LED/SOF) combination therapy in children with chronic hepatitis C genotype 4. The authors investigated the effectiveness of this regimen in achieving sustained virologic response (SVR12), indicating complete viral clearance, in a group of treatment-naive children.

LED/SOF: A Promising Solution for Pediatric Hepatitis C

The study demonstrates the safety and efficacy of the shortened 8-week LED/SOF regimen in children with chronic hepatitis C genotype 4. The authors found that 100% of the patients achieved SVR12, indicating complete viral clearance. Notably, the treatment was well-tolerated, with minimal and tolerable side effects, allowing for a shorter treatment duration and potentially improving adherence.

A Hopeful Journey Through the Desert

This research offers a beacon of hope for children with chronic hepatitis C, providing a safe and effective treatment regimen with a shorter duration. The authors' findings encourage further investigation into the potential of this treatment strategy for other genotypes and patient populations, offering the promise of a more efficient and less burdensome treatment experience. Just as a traveler seeks a shortcut through the desert, this research provides a more direct path to achieving long-term viral clearance for children with chronic hepatitis C.

Dr.Camel's Conclusion

This study offers a promising shortcut through the desert of hepatitis C treatment. The shortened LED/SOF regimen demonstrates impressive efficacy and safety in children with chronic hepatitis C genotype 4. This research provides a ray of hope for patients seeking a quicker and more convenient path to achieving long-term viral clearance.

Date :
  1. Date Completed 2020-09-10
  2. Date Revised 2020-12-10
Further Info :

Pubmed ID

32008767

DOI: Digital Object Identifier

10.1016/j.jpeds.2019.12.034

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・Side Effects of ledipasvir and sofosbuvir
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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