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Protective Effects of Evening Primrose Oil against Cyclophosphamide-Induced Biochemical, Histopathological, and Genotoxic Alterations in Mice.

Author: Abdel-DaimMohamed M, AbushoukAbdelrahman I, KhodeerDina M, MehannaEman T

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Pretreatment with evening primrose oil (EPO) was found to significantly protect mice from the toxic effects of cyclophosphamide (CP) in the liver and pancreas. EPO demonstrated antioxidant, anti-inflammatory, and genoprotective effects, improving biochemical parameters and ameliorating histopathological alterations.
Paper Details　
Original Abstract of the Article :
Cyclophosphamide (CP) is a well-known antineoplastic agent; however, its clinical use can be associated with various organ toxicities. Evening primrose oil (EPO) contains several phytoconstituents with potent anti-oxidant and anti-inflammatory activities. This experimental study was performed to inv...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7168665/

データ提供：米国国立医学図書館（NLM）

Evening Primrose Oil: A Potential Protector Against Chemotherapy Toxicity

Chemotherapy is a powerful cancer treatment, but it can also cause significant side effects, including damage to organs like the liver and pancreas. This study investigates the protective effects of evening primrose oil (EPO) against cyclophosphamide (CP)-induced toxicity in mice. EPO contains various phytoconstituents known for their antioxidant and anti-inflammatory properties.

EPO: Protecting Against Chemotherapy-Induced Toxicity

The study found that EPO significantly mitigated CP-induced damage to the liver and pancreas in mice. EPO pretreatment reduced the levels of liver enzymes, pancreatic amylase, and malondialdehyde (a marker of oxidative stress), and increased serum insulin levels. EPO also improved tissue architecture, reducing inflammation and DNA fragmentation in both the liver and pancreas.

A Promising Approach to Mitigating Side Effects

This research suggests that EPO may have potential as a protective agent against chemotherapy-induced toxicity. Further investigation is needed to explore the potential clinical benefits of EPO in humans undergoing chemotherapy.

Dr. Camel's Conclusion

Think of a camel's ability to store water in its hump, a natural defense against the harsh desert environment. EPO, like a camel's hump, provides a natural defense against the potential toxicity of chemotherapy. This study suggests that EPO could be a valuable tool in mitigating the side effects of cancer treatment, potentially improving the quality of life for patients undergoing chemotherapy.

Date :
  1. Date Completed n.d.
  2. Date Revised 2020-09-28
Further Info :

Pubmed ID

32033362

DOI: Digital Object Identifier

PMC7168665

Related Literature

Article Analysis
・Effective treatment of evening primrose oil
SNS
PICO Info
in preparation
Languages

English

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