Use of <i>Ex</i> <i>Vivo</i> Patient-Derived Tumor Organotypic Spheroids to Identify Combination Therapies for <i>HER2</i> Mutant Non-Small Cell Lung Cancer.

Author: ArefAmir A, BahcallMagda, BarbieDavid A, BarbieThanh U, ChambersEmily S, ChenTing, ChoiJihyun, DahlbergSuzanne E, DialaIrmina, HaworthJacob J, IvanovaElena, JännePasi A, KuraguchiMari, LalaniAlshad S, LiShuai, LiuShengwu, OxnardGeoffrey R, PaweletzCloud P, PortellAndrew J, TausLuke, WongKwok-Kin, XuMan

Paper Details 
Original Abstract of the Article :
Label="PURPOSE">Evaluating drug responses using primary patient-derived cells <i>ex vivo</i> represents a potentially rapid and efficient approach to screening for new treatment approaches. Here, we sought to identify neratinib combinations in <i>HER2</i> mutant non-small cell lung cancer (NSCLC) pa...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元:
https://pubmed.ncbi.nlm.nih.gov/32034078

データ提供:米国国立医学図書館(NLM)

Seeking New Oasis in HER2 Mutant NSCLC: Combining Therapies

The fight against non-small cell lung cancer (NSCLC) is a constant struggle, with researchers seeking new weapons to combat this relentless foe. This research explores the potential of combining different therapies to target HER2 mutant NSCLC. It utilizes a novel approach of using patient-derived organotypic spheroids (XDOTS) to evaluate the effectiveness of neratinib in combination with other drugs. The authors hope to identify synergistic combinations that effectively target this aggressive cancer, potentially offering a new path to improved treatment outcomes. This research is like searching for a hidden oasis in the desert of cancer research, seeking new and effective strategies to combat this deadly disease.

Combination Therapy: A New Strategy for HER2 Mutant NSCLC

This study represents a promising step forward in the fight against HER2 mutant NSCLC. It explores the potential of combination therapy, a strategy that has shown great promise in various cancer types. By targeting different pathways within the cancer cells, combination therapies can potentially overcome resistance to single-agent treatments, offering hope for improved outcomes for patients. It's like deploying a multi-pronged attack against a fortified desert fortress, aiming to weaken its defenses and ultimately achieve victory.

Personalized Approaches to Cancer Treatment: A Future of Hope

This research emphasizes the growing importance of personalized approaches to cancer treatment, recognizing that each patient's cancer is unique. By utilizing patient-derived organotypic spheroids, researchers can tailor treatment plans to individual patients' needs, potentially leading to more effective and targeted therapies. This is like tailoring a camel's journey based on its individual strengths and weaknesses, ensuring its survival and success in the harsh desert environment.

Dr. Camel's Conclusion

This study highlights the importance of innovation and collaboration in the fight against cancer. By exploring new approaches, such as combination therapy and personalized medicine, we can unlock new pathways to effective treatment and improve the lives of those living with this devastating disease. It's a reminder that the desert of cancer research is vast and unforgiving, but with dedication and perseverance, we can find new oases of hope and healing.

Date :
  1. Date Completed 2021-02-04
  2. Date Revised 2022-01-21
Further Info :

Pubmed ID

32034078

DOI: Digital Object Identifier

NIHMS1559383

Related Literature

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.