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Tolerability of Cefazolin and Ceftibuten in Patients with IgE-Mediated Aminopenicillin Allergy.

Author: CarusoCristiano, GaetaFrancesco, QuaratinoDonato, RomanoAntonino, ValluzziRocco Luigi, ZaffiroAlessandra

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Subjects with an IgE-mediated hypersensitivity to penicillins could be treated with cephalosporins such as cefazolin and ceftibuten, which have side-chain determinants different from those of penicillins. However, pretreatment skin tests are advisable because of the possibility of coexisting sensitivities or a sensitivity to an antigenic determinant of the common β-lactam ring.
Paper Details　
Original Abstract of the Article :
BACKGROUND: Side-chain similarities or identities constitute the predominant factor for cross-reactivity between penicillins and cephalosporins, whereas differences in the side-chain structure seem to account for the absence of such cross-reactivity. OBJECTIVE: We sought to assess the cross-reactiv...See full text at original site
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引用元：
https://doi.org/10.1016/j.jaip.2020.02.025

データ提供：米国国立医学図書館（NLM）

A Safe Alternative for Penicillin-Allergic Patients: Exploring Cefazolin and Ceftibuten

This study investigates the cross-reactivity between penicillins and two cephalosporins, cefazolin and ceftibuten, in patients with IgE-mediated aminopenicillin allergy. The study aimed to assess the possibility of using these cephalosporins in penicillin-allergic individuals. The researchers conducted a prospective study of 131 patients with documented penicillin allergy and positive skin test results. Skin tests and challenges with cefazolin and ceftibuten were performed on these patients.

Cefazolin and Ceftibuten: Potential Alternatives for Penicillin-Allergic Individuals

The study found that cefazolin and ceftibuten were well-tolerated in patients with IgE-mediated penicillin allergy. The researchers concluded that these cephalosporins, which have side chains different from those of penicillins, could be considered as alternative treatments for penicillin-allergic individuals. However, they emphasized the need for pretreatment skin tests to rule out any possible coexisting sensitivities.

Navigating Medication Allergies: Understanding Cross-Reactivity

Medication allergies can pose a significant challenge for patients and healthcare professionals. Understanding the potential for cross-reactivity between different drug classes is crucial for making safe and effective treatment decisions. Think of it as crossing a desert with multiple paths – each path has its own risks and benefits, and careful consideration is needed to avoid potential hazards.

Dr. Camel's Conclusion

This study provides valuable information about the safety of cefazolin and ceftibuten in penicillin-allergic patients. The findings offer a potential solution for patients who need alternative β-lactam antibiotics. Like a desert traveler carefully choosing their route based on the terrain and potential dangers, healthcare providers can use this information to navigate medication allergies and ensure the safe and effective treatment of their patients.
Date :
  1. Date Completed 2021-05-14
  2. Date Revised 2021-05-14
Further Info :

Pubmed ID

32145403

DOI: Digital Object Identifier

10.1016/j.jaip.2020.02.025

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Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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