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[Breakthrough of invasive fungal disease with posaconazole as primary prophylaxis after induction chemotherapy for acute myeloid leukemia].

Author: CaoJ J, ChenD, ChenL G, DuX H, LiS Y, LiuX H, LuY, PeiR Z, ShaK Y, TangS H, ZhangP S, ZhuangX X

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

This study evaluated the efficacy and safety of posaconazole and voriconazole as primary prophylaxis for invasive fungal disease (IFD) during induction chemotherapy for acute myeloid leukemia (AML). Posaconazole and voriconazole decreased the incidence of IFD compared with no prophylaxis.
Paper Details　
Original Abstract of the Article :
<b>Objective:</b> To investigate the breakthrough incidence of invasive fungal disease(IFD) and side effects of posaconazole as primary prophylaxis during induction chemotherapy for acute myeloid leukemia(AML). <b>Methods:</b> A total of 206 newly diagnosed AML patients admitted to our department d...See full text at original site
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引用元：
https://doi.org/10.3760/cma.j.issn.0578-1426.2020.03.008

データ提供：米国国立医学図書館（NLM）

Fungal Infections in the Desert of Leukemia: Posaconazole Emerges as a Powerful Protector

Acute myeloid leukemia (AML) is a formidable adversary, challenging the immune system and leaving patients vulnerable to infections. This study delves into the desert of AML, examining the efficacy of posaconazole as a primary prophylaxis for invasive fungal disease (IFD). The researchers compared the efficacy of posaconazole to voriconazole and a control group, finding that both posaconazole and voriconazole significantly reduced the incidence of IFD. Furthermore, posaconazole exhibited a superior safety profile compared to voriconazole.

Posaconazole: A Shield Against Fungal Infections in the Desert of AML

The study demonstrates the effectiveness of posaconazole as a primary prophylaxis for IFD in patients with AML. This finding is a beacon of hope in the desert of AML, providing a valuable tool for protecting patients from potentially life-threatening fungal infections.

Navigating the AML Landscape: A Compass for Infection Prevention

The study emphasizes the importance of antifungal prophylaxis in AML patients, highlighting the efficacy and safety of posaconazole. This research provides valuable insights for healthcare providers, guiding them in their efforts to prevent IFD and improve patient outcomes.

Dr. Camel's Conclusion

This study underscores the importance of antifungal prophylaxis in patients with AML. The findings demonstrate the efficacy of posaconazole in preventing IFD and highlight its superior safety profile compared to voriconazole. This research contributes valuable knowledge to the fight against AML and its associated complications.

Date :
  1. Date Completed 2020-04-03
  2. Date Revised 2020-04-03
Further Info :

Pubmed ID

32146748

DOI: Digital Object Identifier

10.3760/cma.j.issn.0578-1426.2020.03.008

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Article Analysis
・Side Effects of posaconazole
SNS
PICO Info
in preparation
Languages

Chinese

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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