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Intranasal administration of dantrolene increased brain concentration and duration.
Author: EckenhoffMaryellen F, LiangGe, MengQingcheng, ShiYun, WangJintao, WangYan, WeiHuafeng, YuShuchun
Original Abstract of the Article :
Dantrolene has been demonstrated to be neuroprotective for multiple neurodegenerative diseases. However, dantrolene's limited penetration into the CNS hampers its effectiveness as a neuroprotective agent. Here, we studied whether the intranasal administration of dantrolene provided better penetratio...See full text at original site
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難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。
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* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。
引用元:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7065741/
データ提供:米国国立医学図書館(NLM)
Dantrolene: Crossing the Brain's Desert with Intranasal Administration
Dantrolene, a medication known for its neuroprotective properties, has been a subject of intense research, particularly in the field of neurodegenerative diseases. However, its ability to effectively reach the brain, like navigating a vast, impenetrable desert, has presented a major obstacle. This research explores a novel approach to enhancing dantrolene's brain penetration by administering it intranasally. The authors compared the intranasal route to the commonly used oral method and found that intranasal administration significantly increased dantrolene concentrations in the brain, extending its duration of action. This discovery could pave the way for more effective treatments for a range of neurodegenerative conditions.
Intranasal Dantrolene: A New Route to the Brain's Oasis
The study highlights the promising potential of intranasal dantrolene delivery. The findings suggest that intranasal administration, like a newly discovered oasis in the desert, provides a more efficient pathway for dantrolene to reach the brain. This approach could lead to more effective treatment options for neurodegenerative diseases, potentially improving the quality of life for millions of individuals.
Navigating the Brain's Desert: Intranasal Dantrolene Offers a New Path
The intranasal route for dantrolene administration offers a promising approach for maximizing its therapeutic effect. This research adds to the growing body of evidence supporting intranasal drug delivery as a viable and effective method for delivering medication to the brain. It's important to note, like navigating a desert, that this approach may not be suitable for everyone. Always discuss any potential treatment options with your healthcare provider.
Dr.Camel's Conclusion
This research offers a new and promising path for dantrolene to reach the brain's oasis. Intranasal administration could lead to more effective treatments for neurodegenerative diseases, providing a much-needed solution for navigating the difficult landscape of these conditions. However, as with any new approach, it's essential to consult with your healthcare provider to determine if this method is right for you.
Date :
- Date Completed 2020-06-19
- Date Revised 2020-11-18
Further Info :
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English
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