Paper Details 
Original Abstract of the Article :
Isotretinoin is chemically named as: (2Z, 4E, 6E, 8E)-3,7-Dimethyl-9-(2,6,6-trimethylcyclohex-1-enyl)nona-2,4,6,8-tetraenoic acid. It is an orally active retinoic acid derivative for the treatment of severe refractory nodulocystic acne. It acts primarily by reducing sebaceous gland size and sebum pr...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元:
https://doi.org/10.1016/bs.podrm.2019.10.005

データ提供:米国国立医学図書館(NLM)

Isotretinoin: A Powerful Weapon Against Acne, But Not Without Its Risks

The field of dermatology is constantly seeking innovative solutions for the treatment of stubborn skin conditions. This research dives deep into the world of isotretinoin, a potent oral retinoid known for its effectiveness in managing severe acne. The study employs a comprehensive approach, delving into the chemical makeup, preparation methods, and pharmacological actions of isotretinoin. The authors meticulously unravel the secrets behind this medication, shedding light on its mechanism of action and its impact on sebaceous gland function. This research is like a treasure map guiding us through the intricate workings of isotretinoin, revealing its strengths and potential pitfalls. The authors highlight the remarkable efficacy of isotretinoin in achieving significant clearance of inflammatory lesions in acne patients. However, they also emphasize the importance of careful consideration due to the potential side effects, particularly concerning its contraindication for women of childbearing age. This research serves as a valuable guide for dermatologists, offering insights into the appropriate use and management of isotretinoin.

Isotretinoin: A Miracle Cure or a Double-Edged Sword?

This research reveals the impressive efficacy of isotretinoin in achieving significant improvement in acne. The study shows that using isotretinoin for 1-2mg/kg/day for 3-4 months results in 60%-95% clearance of inflammatory lesions in patients with acne. This is a significant finding, highlighting the potential of isotretinoin to dramatically improve the lives of those struggling with severe acne. However, it is important to recognize the double-edged nature of this medication. The research underscores the crucial importance of careful monitoring and responsible use of isotretinoin, given its potential side effects.

Navigating The Desert of Side Effects

The research highlights the potential side effects of isotretinoin, including those affecting the mucocutaneous system and elevated serum triglyceride levels. This emphasizes the importance of a thorough assessment of individual patient risks and benefits before prescribing isotretinoin. It's like navigating a vast desert; while the oasis of clearer skin may be tempting, one must be prepared for the potential challenges along the way. The strict contraindication for women of childbearing age is a crucial piece of information. It is imperative for healthcare professionals to educate patients about the potential risks and implications of using isotretinoin.

Dr.Camel's Conclusion

Isotretinoin is a powerful tool in the arsenal of dermatologists, offering significant hope for patients with severe acne. However, it is not a cure-all. Like a well-trained camel navigating a challenging desert, healthcare providers must carefully weigh the potential benefits and risks of isotretinoin, ensuring its use is appropriate and safe for individual patients.

Date :
  1. Date Completed 2020-07-13
  2. Date Revised 2020-07-13
Further Info :

Pubmed ID

32164966

DOI: Digital Object Identifier

10.1016/bs.podrm.2019.10.005

Related Literature

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.