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Neuroprotective effects of ranolazine versus pioglitazone in experimental diabetic neuropathy: Targeting Nav1.7 channels and PPAR-γ.
Author: El-GawlyHoda W, El-SherbeenyNagla A, ElaidySamah M, ElkholyShereen E, ToraihEman A
Original Abstract of the Article :
Diabetic neuropathy (DN) is a common complication of diabetes mellitus (DM). Pathophysiology of DN includes inflammation and changes in expression and function of voltage-gated sodium channels (Nav) in peripheral nerves; and central reduction of Peroxisome Proliferator Activated Receptor-Gamma (PPAR...See full text at original site
Dr.Camel's Paper Summary Blogラクダ博士について
ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。
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* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。
引用元：
https://doi.org/10.1016/j.lfs.2020.117557
データ提供：米国国立医学図書館（NLM）
Navigating Diabetic Neuropathy: A Quest for Nerve Protection
Diabetic neuropathy, a common complication of diabetes, affects the nerves and can lead to pain, numbness, and weakness. This study explores the potential of two drugs, ranolazine and pioglitazone, to protect nerves in diabetic neuropathy. The authors delve into the complex mechanisms underlying diabetic neuropathy, focusing on the roles of voltage-gated sodium channels and Peroxisome Proliferator Activated Receptor-Gamma (PPAR-γ). This research offers valuable insights into potential therapeutic targets for combating diabetic neuropathy.
Hope on the Horizon: New Approaches to Nerve Protection
Diabetic neuropathy can be a debilitating condition for those living with diabetes. This study suggests that ranolazine and pioglitazone, by targeting specific pathways involved in nerve damage, could offer protection for nerves affected by diabetic neuropathy. Further research is needed to fully understand the efficacy and safety of these drugs in treating diabetic neuropathy.
Living Well with Diabetes: Protecting Your Nerves
Diabetic neuropathy is a serious complication that can significantly impact quality of life. This study provides promising avenues for research, potentially leading to new treatments for diabetic neuropathy. Remember, maintaining good blood sugar control is crucial for preventing or delaying diabetic neuropathy. Consult your doctor to discuss ways to manage your diabetes and protect your nerves.
Dr. Camel's Conclusion
Diabetic neuropathy is a daunting condition, but this research offers a glimmer of hope for finding effective treatments. Much like a desert traveler seeking a refreshing oasis, those with diabetic neuropathy need new solutions to alleviate their symptoms. This research provides valuable insights into potential therapeutic targets for protecting nerves and improving the lives of people living with diabetes.
Date :
- Date Completed 2020-05-05
- Date Revised 2020-05-05
Further Info :
Related Literature
English
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