Netupitant/palonosetron (NEPA) and dexamethasone for prevention of emesis in breast cancer patients receiving adjuvant anthracycline plus cyclophosphamide: a multi-cycle, phase II study.

Author: AmaducciLaura, BilanciaDomenico, BonizzoniErminio, CaputoRoberta, CazzanigaMarina Elena, CelioLuigi, CilentiGiuseppina, CollovàElena, De LaurentiisMichelino, De PlacidoSabino, FabiAlessandra, GiordanoMonica, GuarneriValentina, MontesarchioVincenzo, ParisIda, SbranaAndrea, SchironeAlessio, TorrisiRosalba

Paper Details 
Original Abstract of the Article :
NEPA is an oral fixed-dose combination of netupitant, a new highly selective neurokinin-1 receptor antagonist, and palonosetron. This study was conducted to evaluate whether the efficacy of NEPA against chemotherapy-induced nausea and vomiting (CINV) in cycle 1 would be maintained over subsequent ch...See full text at original site
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引用元:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7081578/

データ提供:米国国立医学図書館(NLM)

NEPA: A Powerful Oasis in the Desert of Chemotherapy-Induced Nausea and Vomiting

Chemotherapy, like a relentless desert heat, can bring about unpleasant side effects, including nausea and vomiting. This research investigates the efficacy of netupitant/palonosetron (NEPA) in preventing chemotherapy-induced nausea and vomiting (CINV) in breast cancer patients receiving adjuvant anthracycline plus cyclophosphamide (AC). The authors, like scientists searching for a cooling respite in the desert of chemotherapy side effects, evaluate the effectiveness of NEPA over multiple cycles of chemotherapy.

NEPA: A Consistent Protector Against Chemotherapy-Induced Nausea and Vomiting

This study, like a well-stocked oasis in the desert of CINV, demonstrates the consistent efficacy of NEPA in preventing nausea and vomiting across multiple chemotherapy cycles. The authors, like meticulous cartographers, map out the effectiveness of NEPA, highlighting its ability to control CINV on both early and late days after chemotherapy. This research, like a clear map guiding us through the complexities of CINV management, provides valuable information for clinicians seeking effective solutions for their patients.

Navigating the Desert of Chemotherapy Side Effects

This study, like a beacon in the desert of chemotherapy side effects, underscores the importance of personalized treatment approaches to minimize patient discomfort. The authors, like astute desert guides, carefully navigate the complexities of CINV, providing valuable information for patients and clinicians seeking effective solutions. This research, like a well-stocked oasis, offers hope for a brighter future in the management of CINV, offering patients a better chance to navigate the challenges of chemotherapy with greater comfort and well-being.

Dr.Camel's Conclusion

This study, like a refreshing spring in the desert of chemotherapy side effects, provides valuable insights into the efficacy of NEPA in preventing CINV. The authors, like seasoned desert guides, carefully navigate the complexities of clinical trials, offering valuable information for patients and clinicians seeking effective solutions. These findings offer hope for a brighter future in the management of CINV, offering patients a better chance to navigate the challenges of chemotherapy with greater comfort and well-being.

Date :
  1. Date Completed 2020-11-06
  2. Date Revised 2020-11-06
Further Info :

Pubmed ID

32188417

DOI: Digital Object Identifier

PMC7081578

Related Literature

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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