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Comparison of Hemorrhagic Risk between Prasugrel and Clopidogrel: a Retrospective Study using Adverse Drug Event Reporting Databases.

Author: FukutaHidekatsu, HagiwaraHiromi, IshizawaKeisuke, KamiyaTakeshi, KimuraKazunori, NiimuraTakahiro, OhteNobuyuki, ZamamiYoshito

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Prasugrel, a potent platelet aggregation inhibitor, has been shown to reduce ischemic events but increase hemorrhagic risk compared to clopidogrel. This real-world analysis of adverse drug event reports confirmed that prasugrel is associated with a higher hemorrhagic risk compared to clopidogrel in patients with acute coronary syndrome scheduled for percutaneous coronary intervention.
Paper Details　
Original Abstract of the Article :
<b>Background</b>: Prasugrel inhibits platelet aggregation more potently and exerts therapeutic action faster than clopidogrel. In the global phase III trial conducted in Western and South American countries that excluded Asian countries, prasugrel reduced ischemic events but increased hemorrhagic ...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7085259/

データ提供：米国国立医学図書館（NLM）

Comparison of Hemorrhagic Risk between Prasugrel and Clopidogrel: A Retrospective Study using Adverse Drug Event Reporting Databases

In the world of [cardiology] and [pharmacovigilance], it’s crucial to understand the potential risks associated with different medications. This study compared the [hemorrhagic risk] of [prasugrel] and [clopidogrel], two drugs commonly used to prevent [blood clots], using data from [adverse drug event reporting databases].

Prasugrel May Have a Higher Hemorrhagic Risk

This study found that [prasugrel] was associated with a higher [hemorrhagic risk] than [clopidogrel] in real-world patients. The researchers analyzed data from [adverse drug event reporting databases] in both Japan and the United States, and their findings suggest that [prasugrel] may be more likely to cause [bleeding].

Understanding Medication Risks

This research highlights the importance of being aware of the potential risks associated with different medications. It underscores the need for careful monitoring and risk assessment when prescribing drugs like [prasugrel] and [clopidogrel].

Dr.Camel's Conclusion

This research reminds us that even in the desert of [medicine], where we strive to improve health, there are always potential risks to consider. It’s essential to weigh the benefits and risks of any medication before making a decision.
Date :
  1. Date Completed 2020-12-23
  2. Date Revised 2020-12-23
Further Info :

Pubmed ID

32218694

DOI: Digital Object Identifier

PMC7085259

Related Literature

Article Analysis
・Side Effects of prasugrel
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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