Paper Details

  1. Home
  2. Paper Details

Hypercalcemia, nephrolithiasis, and hypervitaminosis D precipitated by supplementation in a susceptible individual.

Author: BurmeisterLynn A, HaridasKeerthana, HolickMichael F

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

While generally considered safe, vitamin D supplementation can lead to toxicity, especially in individuals with altered vitamin D catabolism. This case report describes a 58-year-old woman who developed hypercalcemia and nephrolithiasis after receiving vitamin D supplementation. Laboratory testing revealed a high serum calcium, low parathyroid hormone, high 25-hydroxyvitamin D, high 1,25 dihydroxyvitamin D, and a very high ratio of 25(OH)D to 24,25(OH)2D. These findings suggest a potential loss of function mutation in CYP24A1, a key enzyme involved in vitamin D degradation. This case highlights the importance of monitoring serum calcium levels in patients receiving vitamin D supplementation.
Paper Details　
Original Abstract of the Article :
Vitamin D supplementation is common among the general public. Although generally considered safe, vitamin D supplement-induced toxicity has been reported, often in association with manufacturing or labeling errors. Additionally, selected patient populations may have a hypersensitivity to vitamin D s...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://doi.org/10.1016/j.nut.2020.110754

データ提供：米国国立医学図書館（NLM）

Vitamin D Supplementation and Hypercalcemia

The field of [vitamin D metabolism] is always evolving, and this study highlights a crucial aspect: individual variations in how our bodies process vitamin D. The research employed a [case study] approach, focusing on a 58-year-old woman who developed hypercalcemia and kidney stones after taking vitamin D supplements. The researchers delved deeper, discovering that this woman had a genetic predisposition that hindered the breakdown of vitamin D, causing its levels to soar. They also emphasized the importance of [monitoring serum calcium levels] in patients who are taking vitamin D supplements.

A Genetic Twist to Vitamin D Metabolism

This study sheds light on the importance of personalized medicine. The patient's unique genetic makeup made her particularly susceptible to vitamin D toxicity, highlighting the need for careful consideration of individual needs when prescribing supplements. The researchers observed a [high ratio of 25(OH)D to 24,25(OH)2D], indicating an impaired ability to break down vitamin D, which can lead to hypercalcemia and other health complications.

Navigating the Desert of Vitamin D

Think of it this way: Our bodies are like a vast desert, and vitamin D is like a precious oasis. We need a healthy balance to thrive, but too much vitamin D can be just as detrimental as too little. Just as a traveler in the desert needs to carefully manage their water intake, individuals need to be aware of their vitamin D needs and consult with healthcare professionals to avoid excessive supplementation.

Dr. Camel's Conclusion

This research serves as a reminder that we are all unique, and the way our bodies process nutrients can vary significantly. It emphasizes the importance of personalized medicine and the need to monitor our vitamin D levels, especially when taking supplements. It's like a wise traveler in the desert, knowing when to replenish their water supply and when to avoid overindulging to avoid dehydration.

Date :
  1. Date Completed 2021-06-23
  2. Date Revised 2022-05-31
Further Info :

Pubmed ID

32222584

DOI: Digital Object Identifier

10.1016/j.nut.2020.110754

Related Literature

Article Analysis
・Effective treatment of functional medicine
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.