Paper Details 
Original Abstract of the Article :
The aim of the present study was to explore the ameliorative role of imatinib and tetrabenazine in acute stress-induced behavioural and biochemical changes in mice. Cold-water immersion (5 min duration) was employed to induce acute stress and the resulting changes in the locomotor activity, explorat...See full text at original site
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引用元:
https://doi.org/10.1007/s00210-020-01862-w

データ提供:米国国立医学図書館(NLM)

Imatinib and Tetrabenazine: Fighting Stress with a One-Two Punch

Stress, a pervasive force in modern life, can have a profound impact on both physical and mental health. This study investigates the anti-stress effects of imatinib, a tyrosine kinase inhibitor, and tetrabenazine, a vesicular monoamine transporter 2 (VMAT2) inhibitor, in mice subjected to cold-water immersion-induced acute stress. The researchers found that both imatinib and tetrabenazine significantly attenuated stress-induced behavioral alterations and normalized plasma corticosterone levels. This research offers promising insights into the potential of these drugs for mitigating the negative effects of stress, paving the way for new therapeutic approaches to stress management.

Imatinib and Tetrabenazine: A New Frontier in Stress Management

The study's findings suggest that imatinib and tetrabenazine hold significant potential for mitigating the detrimental effects of stress. Their ability to alleviate stress-induced behavioral changes and normalize corticosterone levels offers a promising avenue for developing new therapies to combat stress-related disorders. This research is a valuable contribution to the field of stress management, providing new insights into the potential of these drugs for improving overall well-being.

Combatting Stress: A Multifaceted Approach

Imagine a world where stress is effectively managed, allowing individuals to cope with life's challenges with greater resilience and composure. This research provides valuable insights into the potential of imatinib and tetrabenazine for achieving that goal. Their unique mechanisms of action suggest that they could be valuable tools for combating stress-related disorders, offering a new avenue for improving overall mental and physical health.

Dr.Camel's Conclusion

The desert of stress can be a harsh and unforgiving landscape, leaving individuals feeling overwhelmed and depleted. Imatinib and tetrabenazine, with their ability to combat the physiological and behavioral effects of stress, are like a refreshing oasis in the desert. They provide a respite from the relentless heat and dryness of stress, allowing individuals to regain a sense of balance and peace.

Date :
  1. Date Completed 2021-07-28
  2. Date Revised 2021-07-28
Further Info :

Pubmed ID

32291496

DOI: Digital Object Identifier

10.1007/s00210-020-01862-w

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English

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