Effect of dextromethorphan/quinidine on pentylenetetrazole- induced clonic and tonic seizure thresholds in mice.

Author: HeydariAzhdar, JamaliHassan

Paper Details 
Original Abstract of the Article :
Label="INTRODUCTION">This study aimed to investigate the effects of dextromethorphan (DM) or dextromethorphan/quinidine (DM/Q) against pentylenetetrazole (PTZ)- induced seizure threshold in mice and the probable involvement of N-methyl d-aspartate (NMDA), sigma-1 and serotonin 1A (5-HT<sub>1A</sub>)...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元:
https://doi.org/10.1016/j.neulet.2020.134988

データ提供:米国国立医学図書館(NLM)

Dextromethorphan/Quinidine and Seizures: A New Path in the Desert of Epilepsy

Epilepsy is a challenging neurological disorder, like a desert storm that can disrupt the delicate balance of the brain. This study investigates the potential of dextromethorphan/quinidine to reduce the severity of seizures in mice. The researchers believe this combination, like a desert plant that grows in harsh conditions, may offer a new approach to managing seizures.

Dextromethorphan/Quinidine: A Potential Oasis in the Desert of Seizures

The study found that dextromethorphan/quinidine was effective in raising seizure thresholds in mice, suggesting that it may have anti-seizure properties. This is like finding a hidden spring in the desert, offering a new source of hope for those living with epilepsy. This research provides a basis for further investigation into the potential of this drug combination for treating seizures in humans.

Managing Seizures: Finding New Treatments and Hope

This study is a reminder that the search for new and effective treatments for epilepsy continues. It's like navigating a vast and challenging desert, searching for a path to better health. This research offers a potential new avenue for managing seizures, giving hope for a brighter future for those living with this complex disorder.

Dr.Camel's Conclusion

This study provides a glimmer of hope in the desert of epilepsy, suggesting that dextromethorphan/quinidine may offer a new approach to managing seizures. It's a reminder that we must continue to explore new frontiers in the fight against epilepsy and develop innovative therapies that can improve the lives of those affected.

Date :
  1. Date Completed 2021-05-14
  2. Date Revised 2021-05-14
Further Info :

Pubmed ID

32325102

DOI: Digital Object Identifier

10.1016/j.neulet.2020.134988

Related Literature

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.