Pharmacokinetics and safety of VALTOCO (NRL-1; diazepam nasal spray) in patients with epilepsy during seizure (ictal/peri-ictal) and nonseizure (interictal) conditions: A phase 1, open-label study.

Author: CarrazanaEnrique, HoganRobert Edward, KleinPavel, MillerIan, RabinowiczAdrian L, SegalEric B, SperlingMichael R, TarquinioDaniel

Paper Details 
Original Abstract of the Article :
OBJECTIVE: To assess pharmacokinetics and safety of diazepam nasal spray (NRL-1; VALTOCO®) in pediatric and adult patients with epilepsy in seizure and nonseizure states. METHODS: A single dose of diazepam nasal spray (5, 10, 15, or 20 mg based on weight) was administered during each of two conditi...See full text at original site
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引用元:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7383779/

データ提供:米国国立医学図書館(NLM)

Navigating the Desert of Epilepsy: Diazepam Nasal Spray in Both Seizure and Non-Seizure States

Epilepsy, a neurological disorder characterized by recurrent seizures, is a challenging condition for both patients and their families. This study dives into the use of diazepam nasal spray, a fast-acting anti-seizure medication, to manage epilepsy in both seizure and non-seizure states. Researchers conducted a clinical trial to assess the pharmacokinetics, the way the drug moves through the body, and safety of diazepam nasal spray in patients with epilepsy. They found that the pharmacokinetic profiles were similar in both seizure and non-seizure conditions, making this medication a valuable tool for managing seizures regardless of the patient's current state.

A Versatile Solution for Epilepsy Management

The study's findings suggest that diazepam nasal spray offers a flexible treatment option for patients with epilepsy. It can be effectively administered both during and between seizures, providing a consistent and predictable response. This versatility could help improve seizure control and potentially reduce the need for other medications. The study also highlighted the overall safety and tolerability of diazepam nasal spray, further solidifying its role as a valuable tool for managing epilepsy.

Easing the Desert Journey with Diazepam Nasal Spray

This research provides valuable insights into the management of epilepsy, a condition that can significantly impact a person's life. Diazepam nasal spray, with its consistent pharmacokinetic profile and broad applicability, offers a potential solution for better seizure control and improved quality of life for patients. This finding represents a significant step forward in the quest for more effective and personalized epilepsy management.

Dr.Camel's Conclusion

This study demonstrates the versatility of diazepam nasal spray, a welcome oasis in the challenging desert of epilepsy treatment. Its ability to effectively manage seizures in both seizure and non-seizure states offers a valuable tool for patients and their caregivers. This discovery offers a glimpse of hope for a future where epilepsy is more effectively managed, allowing patients to navigate their lives with greater confidence and independence.

Date :
  1. Date Completed 2020-11-30
  2. Date Revised 2021-04-09
Further Info :

Pubmed ID

32338380

DOI: Digital Object Identifier

PMC7383779

Related Literature

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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