Daridorexant, a new dual orexin receptor antagonist, in elderly subjects with insomnia disorder.

Author: DauvilliersYves, KunzDieter, MansourYosef, PainScott, Sebök KinterDalma, ZammitGary

Paper Details 
Original Abstract of the Article :
OBJECTIVE: To assess the dose-response of daridorexant, a new dual orexin receptor antagonist, on wake after sleep onset (WASO). METHODS: Elderly (≥65 years) participants (n = 58) with insomnia were randomly allocated (Latin square design) to receive 5 treatments (5, 10, 25, and 50 mg daridorexant ...See full text at original site
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引用元:
https://doi.org/10.1212/WNL.0000000000009475

データ提供:米国国立医学図書館(NLM)

Daridorexant for Insomnia: A Sleep-Inducing Oasis in the Desert of Sleeplessness

The field of [sleep medicine] constantly seeks safe and effective treatments for [insomnia]. This study, utilizing a [dose-response] approach, investigates the efficacy of [daridorexant], a novel [dual orexin receptor antagonist], in treating [insomnia] among [elderly subjects]. The authors aim to determine the optimal dose of daridorexant for reducing [wake after sleep onset (WASO)] and improving sleep quality in this population.

Daridorexant: A Sleep-Inducing Oasis

The study's findings demonstrate a [dose-dependent reduction] in WASO and [latency to persistent sleep (LPS)] following administration of daridorexant. This indicates that daridorexant has a [significant effect] on sleep parameters, potentially improving sleep quality and reducing nighttime awakenings in elderly individuals with insomnia. This discovery is akin to finding a refreshing oasis in the desert of sleeplessness, offering a respite from the debilitating effects of insomnia.

A Good Night's Sleep: A Foundation for Health and Well-being

The study's findings highlight the importance of [quality sleep] for maintaining overall health and well-being, especially in the elderly population. Improved sleep quality can lead to [increased energy levels, improved cognitive function, and enhanced mood], improving the overall quality of life for individuals struggling with insomnia. This research reinforces the idea that a good night's sleep is essential for navigating the challenges of life, just as a reliable source of water is vital for traversing a desert.

Dr. Camel's Conclusion

This study shines a light on the potential of daridorexant to provide much-needed relief for insomnia in the elderly. The findings highlight the importance of addressing sleep disorders and underscore the need for continued research in this critical area of health and well-being.

Date :
  1. Date Completed 2020-09-21
  2. Date Revised 2020-12-10
Further Info :

Pubmed ID

32341187

DOI: Digital Object Identifier

10.1212/WNL.0000000000009475

Related Literature

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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