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Mitotane liposomes for potential treatment of adrenal cortical carcinoma: <i>ex vivo</i> intestinal permeation and <i>in vivo</i> bioavailability.
Author: OliveiraDaniele M L, PintoCesar C, SantanaMaria H A, SeverinoPatrícia, SoutoEliana B, WoiskiThiago D, ZancanellaPatricia, de OliveiraBonald H
Original Abstract of the Article :
The adrenal cortical carcinoma (ACC) treatment, for which mitotane (o,p'-DDD) is the drug of choice, still remains a challenge both because of the well-known solubility problems of the drug, and its serious side effects. Mitotane is currently administered as oral tablets. The loading of mitotane int...See full text at original site
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ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。
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* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。
引用元:
https://doi.org/10.1080/10837450.2020.1762645
データ提供:米国国立医学図書館(NLM)
Mitotane Liposomes: A Promising Solution for Adrenal Cortical Carcinoma
The field of cancer treatment, like a vast and unforgiving desert, is constantly seeking new and innovative approaches to fight this deadly disease. This study, like a team of researchers searching for a hidden oasis, explores the potential of mitotane liposomes to improve the treatment of adrenal cortical carcinoma (ACC). The authors, armed with their knowledge of drug delivery and nanotechnology, investigate the use of liposomes to enhance the absorption and bioavailability of mitotane, a drug with known solubility challenges and significant side effects.Mitotane Liposomes: A Potential Solution for Adrenal Cortical Carcinoma
The authors' findings, like a glimmer of hope in the desert, reveal the potential of mitotane liposomes to enhance the treatment of ACC. Their research demonstrates that encapsulating mitotane in liposomes significantly improves its intestinal absorption and bioavailability, suggesting that this novel formulation could overcome the limitations of traditional oral administration. This discovery is like finding a hidden spring in the desert, offering a potential source of relief and improved outcomes for patients with ACC.A New Era in Adrenal Cortical Carcinoma Treatment
This study is like a trailblazing caravan, opening up new avenues for ACC treatment. The authors' findings suggest that mitotane liposomes could lead to a new era in ACC management, offering a potentially safer and more effective approach to treating this challenging cancer. The research is like a detailed map, guiding us towards a better understanding of the potential of liposomal drug delivery in cancer therapy.Dr. Camel's Conclusion
This study is a testament to the power of innovation in the field of cancer treatment. The authors present compelling evidence for the potential of mitotane liposomes to improve the treatment of ACC, offering a promising new approach to treating this challenging cancer. This research is a reminder that we should continue to explore new frontiers in cancer therapy, seeking to unlock the full potential of nanotechnology and drug delivery systems to improve patient outcomes and combat this deadly disease.Date :
- Date Completed 2021-06-17
- Date Revised 2021-06-17
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