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PI3K Inhibitors and Their Role as Novel Agents for Targeted Therapy in Lymphoma.

Author: AssoulineSarit, Sapon-CousineauSasha, Sapon-CousineauVladimir

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Overview

PI3K inhibitors are a new class of drugs that target a key cellular pathway involved in cell growth and division. These drugs are approved for the treatment of certain types of lymphoma. Although PI3K inhibitors can be effective, they can also cause side effects, including diarrhea, low blood cell counts, and liver problems. More research is needed to better understand how to use these drugs safely and effectively.
Paper Details　
Original Abstract of the Article :
Phosphatidylinositol 3-kinase (PI3K) inhibitors represent a novel class of agents targeting the key cellular regulatory PI3K/AKT/mTOR pathway involved in crucial functions such as cellular proliferation, cell cycle regulation, protein synthesis, and cell motility. This review starts with an overview...See full text at original site
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引用元：
https://doi.org/10.1007/s11864-020-00746-8

データ提供：米国国立医学図書館（NLM）

PI3K Inhibitors: A New Weapon Against Lymphoma

Lymphoma is a type of cancer that affects the lymphatic system, the body's network of vessels and tissues that help fight infection. This study, like a physician wielding a new weapon, explores the potential of PI3K inhibitors in treating lymphoma. The researchers delve into the mechanisms of these inhibitors, their effectiveness in different lymphoma subtypes, and the potential side effects of this targeted therapy.

Targeting the PI3K Pathway: A New Frontier in Lymphoma Treatment

The study highlights the importance of targeting the PI3K/AKT/mTOR pathway, a key signaling pathway involved in cell growth and proliferation, in the fight against lymphoma. It's like identifying a weak point in a fortress, offering a new avenue for attacking cancer cells. The researchers discuss the rationale behind PI3K inhibition and review the clinical trials that have led to the approval of several PI3K inhibitors for the treatment of relapsed and refractory indolent non-Hodgkin lymphoma.

Hope for Improved Outcomes in Lymphoma Treatment

This study offers a glimmer of hope for individuals battling lymphoma, providing evidence for the potential of PI3K inhibitors as a valuable treatment option. It's like discovering a new spring of water in the desert of cancer treatment, offering a source of hope for patients facing this challenging disease. The researchers emphasize the importance of ongoing research to improve the safety and efficacy of PI3K inhibitors, ultimately aiming to improve the lives of those affected by lymphoma.

Dr. Camel's Conclusion

This research represents a significant advancement in the fight against lymphoma. It's like discovering a new oasis in the vast desert of cancer treatment, offering a promising new approach to targeting this disease. The exploration of PI3K inhibitors provides a potential new weapon in our arsenal against this formidable enemy. By continuing to investigate and refine these therapies, we can strive to improve the outcomes and quality of life for individuals living with lymphoma.

Date :
  1. Date Completed 2021-08-09
  2. Date Revised 2021-08-09
Further Info :

Pubmed ID

32356174

DOI: Digital Object Identifier

10.1007/s11864-020-00746-8

SNS
PICO Info
in preparation
Languages

English

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