Combined methazolamide and theophylline improves oxygen saturation but not exercise performance or altitude illness in acute hypobaric hypoxia.

Author: DavisChristopher, EveroOghenero, GronewoldJeffrey, NicholsAndrew J, ReitingerJeremy, RoachRobert C, SubudhiAndrew W, Van-HoutenSonja Jameson

Paper Details 
Original Abstract of the Article :
What is the central question of this study? Does the combination of methazolamide and theophylline reduce symptoms of acute mountain sickness (AMS) and improve aerobic performance in acute hypobaric hypoxia? What is the main finding and its importance? The oral combination of methazolamide (100 BID)...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元:
https://doi.org/10.1113/EP088461

データ提供:米国国立医学図書館(NLM)

Climbing the Mountain of Hypobaric Hypoxia: A Quest for a Better Solution

The study explores the effects of a combination of methazolamide and theophylline on symptoms of acute mountain sickness (AMS) and exercise performance in individuals exposed to acute hypobaric hypoxia. The authors investigate the potential of this drug combination to provide a more effective treatment for those venturing into the harsh environments of high altitude. The study uses a rigorous approach, analyzing the drug combination's impact on oxygen saturation, AMS symptoms, and aerobic performance.

Reaching the Summit: A Search for the Right Path

While the combination of methazolamide and theophylline improved oxygen saturation, it did not significantly reduce AMS symptoms or improve exercise performance. This finding suggests that the researchers have not yet found the optimal path to combat the challenges of acute hypobaric hypoxia. More research is needed to identify more effective solutions for those seeking to conquer the mountains of altitude.

Navigating the High Altitudes of Health: Understanding the Risks

This study highlights the importance of understanding the potential risks and benefits of different treatments. The combination of methazolamide and theophylline, while showing potential for improving oxygen saturation, did not provide the expected benefits in other areas. This emphasizes the need for careful consideration of the potential risks and benefits of any new treatment, particularly in environments like high altitudes where the challenges are magnified.

Dr. Camel's Conclusion

This study offers valuable insights into the complexities of managing acute hypobaric hypoxia. It reminds us that the journey to conquer the mountains of altitude is not always straightforward. We must continue to explore and innovate to find better solutions for those venturing into these challenging environments. This study serves as a reminder that scientific research is an ongoing process, and we must always remain open to new discoveries and approaches to tackle the ever-evolving challenges of human health.

Date :
  1. Date Completed 2022-02-21
  2. Date Revised 2022-02-21
Further Info :

Pubmed ID

32363610

DOI: Digital Object Identifier

10.1113/EP088461

Related Literature

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.