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Benznidazole/Poloxamer 407 Solid Dispersion as a New Strategy to Improve the Treatment of Experimental Trypanosoma cruzi Infection.

Author: BermúdezJosé María, CidAlicia Graciela, DaviesCarolina, MicheloudJuan Francisco, NegretteOlga Sánchez, ParadaLuis Antonio, RagonePaula Gabriela, SimonazziAnalía

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

A new liquid formulation of benznidazole, a drug used for Chagas disease, was developed using the amphiphilic polymer poloxamer 407. The formulation demonstrated equivalent efficacy to the commercial formulation but without significant side effects or hepatotoxicity.
Paper Details　
Original Abstract of the Article :
Benznidazole and nifurtimox are the only drugs specifically approved for the treatment of Chagas disease. Both compounds are given orally in tablets, but occasionally are ineffective and cause adverse effects. Benznidazole, the first-line treatment in many countries, is a compound with low solubilit...See full text at original site
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引用元：
https://doi.org/10.1645/19-80

データ提供：米国国立医学図書館（NLM）

Benznidazole Solid Dispersions: A New Oasis for Chagas Disease Treatment

This research explores a new strategy for improving the treatment of Chagas disease, a parasitic infection that affects millions worldwide. The authors focus on benznidazole, the first-line treatment for Chagas, which often suffers from low solubility and requires high doses for prolonged periods.

A New Formulation: Enhancing Solubility and Efficacy

The authors developed a new liquid formulation of benznidazole based on solid dispersions (SD) using the amphiphilic polymer poloxamer 407. This innovative approach, like finding a hidden spring in the desert, aims to improve the solubility and effectiveness of benznidazole.

Promising Results: Equivalent Efficacy with Fewer Side Effects

Their findings demonstrate that the benznidazole SD formulation was as effective as the commercial formulation but without the associated side effects and hepatotoxicity. This discovery, like finding a safe passage through a treacherous desert, holds great promise for improving the treatment of Chagas disease.

Dr.Camel's Conclusion

This research, like a groundbreaking expedition through the desert of Chagas disease treatment, offers a promising new strategy for improving the efficacy and safety of benznidazole. The development of this liquid formulation, based on solid dispersions, represents a significant step forward in the fight against this neglected tropical disease.
Date :
  1. Date Completed 2020-09-30
  2. Date Revised 2020-09-30
Further Info :

Pubmed ID

32369594

DOI: Digital Object Identifier

10.1645/19-80

Related Literature

Article Analysis
・Side Effects of benznidazole
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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