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Oncogenic effects of RAB27B through exosome independent function in renal cell carcinoma including sunitinib-resistant.

Author: EnokidaHideki, KuroshimaKazuki, NakagawaMasayuki, OkamuraShunsuke, OsakoYoichi, SakaguchiTakashi, SugitaSatoshi, TataranoShuichi, TsurudaMasafumi, YoshinoHirofumi

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

RAB27B, a protein involved in exosome secretion, is highly expressed in renal cell carcinoma (RCC) and is associated with progression of the disease. RAB27B downregulation suppressed cell proliferation, migration, and invasion in both sunitinib-sensitive and -resistant RCC cells. This finding suggests RAB27B as a potential therapeutic target for RCC.
Paper Details　
Original Abstract of the Article :
Exosomes are 40-100 nm nano-sized extracellular vesicles. They are released from many cell types and move into the extracellular space, thereby transferring their components to recipient cells. Exosomes are receiving increasing attention as novel structures participating in intracellular communicati...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7205224/

データ提供：米国国立医学図書館（NLM）

RAB27B: A Potential Oasis in the Desert of Renal Cell Carcinoma

The fight against [renal cell carcinoma (RCC)] is a complex battle, with researchers constantly seeking new targets and therapies. This study explores the role of [RAB27B] in [RCC], including [sunitinib-resistant] forms. The authors found that [RAB27B] expression was significantly increased in [RCC cell lines] and [sunitinib-resistant RCC cell lines], suggesting a potential link between [RAB27B] and [RCC progression] and [sunitinib resistance]. They further demonstrated that [RAB27B] knockdown suppressed [cell proliferation], [migration], and [invasion], highlighting its potential as a therapeutic target for [RCC] treatment.

RAB27B: A New Target in the Desert of Renal Cell Carcinoma

This study identifies [RAB27B] as a potential new target for [RCC] treatment. The significant association between [RAB27B] expression and [RCC progression] and [sunitinib resistance] suggests that targeting [RAB27B] could be a promising strategy for combating this challenging cancer. The study's findings encourage further research into the specific mechanisms of [RAB27B] action and its potential as a therapeutic target for [RCC] treatment, particularly in [sunitinib-resistant] cases.

Navigating the Desert of Renal Cell Carcinoma: Seeking New Pathways to Treatment

The desert of [RCC] can be a formidable landscape to navigate, but this study offers a glimpse of a potential oasis in the form of [RAB27B]. The researchers' findings suggest that targeting [RAB27B] could provide a new pathway for combating this challenging cancer, particularly in [sunitinib-resistant] cases. Further exploration of [RAB27B] as a therapeutic target could lead to more effective and personalized treatment strategies for individuals with [RCC].

Dr. Camel's Conclusion

The battle against [RCC] is like traversing a vast desert, where each step brings new challenges. This study offers a promising oasis, highlighting the potential of [RAB27B] as a therapeutic target. Just as a camel relies on its keen sense of direction to navigate the desert, we must continue to explore new avenues and utilize our scientific knowledge to combat this resilient cancer and find the path towards effective treatments.

Date :
  1. Date Completed 2020-07-28
  2. Date Revised 2020-07-28
Further Info :

Pubmed ID

32379831

DOI: Digital Object Identifier

PMC7205224

Related Literature

Article Analysis
・Effects of sunitinib
SNS
PICO Info
in preparation
Languages

English

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