The effects of combination treatments on drug resistance in chronic myeloid leukaemia: an evaluation of the tyrosine kinase inhibitors axitinib and asciminib.

Author: FriedmanRan, G LindströmH Jonathan

Paper Details 
Original Abstract of the Article :
Chronic myeloid leukaemia is in principle a treatable malignancy but drug resistance is lowering survival. Recent drug discoveries have opened up new options for drug combinations, which is a concept used in other areas for preventing drug resistance. Two of these are (I) Axitinib, which inhibits th...See full text at original site
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引用元:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7204252/

データ提供:米国国立医学図書館(NLM)

Combating Drug Resistance in Chronic Myeloid Leukemia: A New Era of Combination Therapies

This research takes us on a journey through the complex landscape of chronic myeloid leukemia (CML), exploring the growing challenge of drug resistance. The study delves into the potential of combining tyrosine kinase inhibitors, axitinib and asciminib, to combat drug resistance and enhance treatment outcomes. The study investigates the individual mechanisms of action of these drugs, highlighting their potential for synergistic effects in overcoming resistance.

A New Frontier in CML Treatment: The Power of Combinations

This research underscores the importance of investigating combination therapies as a potential strategy to combat drug resistance in CML. The study's findings suggest that combining axitinib and asciminib could offer a promising approach to overcoming resistance, paving the way for more effective and sustained treatment for individuals with CML.

Navigating the Labyrinth of CML Treatment

This research, like a camel navigating a complex labyrinth, explores the challenging landscape of CML treatment, seeking to overcome the hurdle of drug resistance. The study's findings highlight the potential of combination therapies, offering hope for individuals with CML. Further research is crucial to fully understand the efficacy and safety of these combinations in clinical settings, guiding clinicians in developing more effective treatment strategies.

Dr. Camel's Conclusion

This research explores the potential of combining tyrosine kinase inhibitors, axitinib and asciminib, to combat drug resistance in chronic myeloid leukemia. The study's findings suggest that combining these drugs could offer a promising approach to overcoming resistance, paving the way for more effective and sustained treatment for individuals with CML.

Date :
  1. Date Completed 2020-12-16
  2. Date Revised 2020-12-16
Further Info :

Pubmed ID

32380976

DOI: Digital Object Identifier

PMC7204252

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Languages

English

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