Paper Details

  1. Home
  2. Paper Details

Neuroprotective Effects of Lacosamide and Memantine on Hyperoxic Brain Injury in Rats.

Author: AyanoğluMüge, BayramErhan, Cilaker MıcılıSerap, EdemPınar, Hız KurulSemra, OkurDerya, PaketçiCem, Polatİpek, TuğyanKazım, YişUluç, YılmazOsman, ÇalışırMeryem

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Memantine treatment reduced neuron death and apoptosis in newborn rat brains after hyperoxia exposure. This study is the first to show the effects of memantine and lacosamide on hyperoxia-induced damage in neonatal rat brains.
Paper Details　
Original Abstract of the Article :
In neonates supraphysiological oxygen therapy has been demonstrated to cause neuronal death in hippocampus, prefrontal cortex, parietal cortex, and retrosplenial cortex. There is a need for the detection of novel neuroprotective drugs. Neuroprotective effects of lacosamide or memantine have been dem...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://doi.org/10.1007/s11064-020-03056-5

データ提供：米国国立医学図書館（NLM）

Neuroprotective Effects of Lacosamide and Memantine on Hyperoxic Brain Injury

The delicate brain of a newborn is incredibly vulnerable, like a fragile desert flower in a harsh environment. This research investigates the neuroprotective effects of lacosamide and memantine, two medications, on hyperoxic brain injury in rats. The study explores the potential of these drugs to protect developing brains from damage caused by excessive oxygen exposure, a condition that can arise during medical interventions for newborns.

Protecting Developing Brains: Exploring Neuroprotective Strategies

The findings suggest that memantine treatment may reduce neuronal death and apoptosis in newborn rat brains exposed to hyperoxia. This is like providing a protective shield to a fragile desert flower during a sandstorm. The study offers a promising avenue for exploring the potential of memantine as a neuroprotective agent in newborns at risk of hyperoxic brain injury.

Safeguarding the Future: New Approaches to Brain Protection

This research emphasizes the importance of finding effective neuroprotective strategies for newborns at risk of hyperoxic brain injury. It's like discovering a hidden spring in the desert that provides a vital source of water for vulnerable life. The study's findings could lead to new therapeutic approaches that protect the developing brains of newborns and safeguard their future health.

Dr.Camel's Conclusion

This study explores the potential of memantine as a neuroprotective agent in newborns exposed to hyperoxic brain injury. It's like discovering a powerful oasis in the heart of a desert – offering hope for protecting vulnerable brains from damage. While further research is needed to confirm its efficacy and safety in humans, this study provides a promising starting point for exploring new therapeutic options to protect the developing brains of newborns.

Date :
  1. Date Completed 2021-06-03
  2. Date Revised 2021-06-03
Further Info :

Pubmed ID

32444924

DOI: Digital Object Identifier

10.1007/s11064-020-03056-5

Related Literature

Article Analysis
・Effects of lacosamide
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.