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A newborn with a large NTRK fusion positive infantile fibrosarcoma successfully treated with larotrectinib.

Author: CaldwellKenneth J, De La CuestaEsther, HelmigSara, MorinCara, PappoAlberto

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

This case report describes a newborn with infantile fibrosarcoma (IFS) who experienced a rapid clinical and radiographic response to larotrectinib treatment.
Paper Details　
Original Abstract of the Article :
Infantile fibrosarcoma (IFS) is a rare pediatric cancer that typically presents early in life. Surgical resection is commonly curative; however, resection is sometimes not possible requiring additional multimodal treatment. IFS commonly harbors a fusion in one of the neurotrophic receptor tyrosine k...See full text at original site
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引用元：
https://doi.org/10.1002/pbc.28330

データ提供：米国国立医学図書館（NLM）

Larotrectinib: A New Hope for Infantile Fibrosarcoma?

This study embarks on a journey into the [realm of infantile fibrosarcoma (IFS)], a rare and aggressive pediatric cancer. The research focuses on the use of [larotrectinib], a targeted therapy, in the treatment of a newborn with IFS. The authors, like skilled surgeons meticulously operating on a delicate tissue, document the [successful treatment of a newborn with IFS] using larotrectinib, highlighting the potential of this drug for [treating young patients with IFS].

Larotrectinib: A Promising Treatment for Infantile Fibrosarcoma in Newborns

This study, like a spring of water in the desert, offers a glimmer of hope for newborns with IFS. The successful treatment of a newborn with larotrectinib highlights the potential of this drug in [providing effective therapy for this rare and challenging cancer] in young patients.

Larotrectinib: A Potential Game-Changer for Infantile Fibrosarcoma

This study, like a rare desert flower, showcases the promising potential of larotrectinib in treating IFS. The successful treatment of a newborn with IFS offers hope for [developing effective treatments for this aggressive cancer] and improving outcomes for young patients.

Dr. Camel's Conclusion

This research, like a camel caravan delivering vital supplies to a remote village, offers a beacon of hope for newborns with IFS. The successful treatment of a newborn with larotrectinib highlights the potential of this drug in treating this rare and aggressive cancer, paving the way for future research and improved outcomes for young patients.
Date :
  1. Date Completed 2020-12-10
  2. Date Revised 2021-11-04
Further Info :

Pubmed ID

32452122

DOI: Digital Object Identifier

10.1002/pbc.28330

Related Literature

Article Analysis
・Effects of larotrectinib
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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