Paper Details

  1. Home
  2. Paper Details

Systematic review with meta-analysis: efficacy and safety of treatments for opioid-induced constipation.

Author: CamilleriMichael, ErwinPatricia, MuradM Hassan, VijayvargiyaPooja, VijayvargiyaPriya

Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Overview

Peripherally acting μ-opioid receptor antagonists (PAMORAs) were more effective than other treatments in relieving opioid-induced constipation. Methylnaltrexone, naloxegol, and naldemidine were the most effective PAMORAs and were associated with a low risk of serious adverse events.
Paper Details　
Original Abstract of the Article :
BACKGROUND: When opioid-induced constipation is treated with centrally acting opioid antagonists, there may be opioid withdrawal or aggravation of pain due to inhibition of μ-opioid analgesia. This led to the development of peripherally acting μ-opioid receptor antagonists (PAMORAs). AIM: To evalua...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://doi.org/10.1111/apt.15791

データ提供：米国国立医学図書館（NLM）

Tackling Opioid-Induced Constipation: A Comprehensive Review

Opioid-induced constipation is a common and often challenging side effect of opioid medications. This systematic review delves into the vast landscape of treatments for this condition, examining the effectiveness and safety of various approaches. It’s like a seasoned desert explorer charting a course through a complex and often unpredictable terrain, seeking the best pathways to relief.

Finding Relief for Opioid-Induced Constipation

The review systematically analyzes data from multiple clinical trials, revealing that peripherally acting μ-opioid receptor antagonists (PAMORAs) are the most effective treatments for opioid-induced constipation. This is like discovering a hidden oasis in the desert, providing a much-needed source of relief. The review highlights the efficacy of specific PAMORAs like methylnaltrexone, naloxegol, and naldemidine in alleviating constipation, offering a beacon of hope for patients struggling with this common side effect.

Navigating the Side Effects of Opioid Use

Opioids are powerful medications that can provide significant pain relief, but they can also have unwanted side effects. This review underscores the importance of managing these side effects, especially constipation, to improve patients’ quality of life. It's like using a compass to guide us through the complex terrain of opioid therapy, ensuring that we reach our destination safely and effectively. This research provides valuable insights for physicians and patients alike, helping them navigate the complexities of opioid use and manage potential side effects.

Dr. Camel's Conclusion

The review provides a comprehensive overview of treatment options for opioid-induced constipation, serving as a valuable guide for both patients and healthcare providers. This research emphasizes the importance of managing side effects to optimize the benefits of opioid therapy and improve patients’ overall health and well-being. It's like finding a reliable guide in the vast desert of opioid therapy, providing a clear path to a more comfortable and fulfilling life.

Date :
  1. Date Completed 2020-10-22
  2. Date Revised 2020-10-22
Further Info :

Pubmed ID

32462777

DOI: Digital Object Identifier

10.1111/apt.15791

Related Literature

Article Analysis
・Effects of linaclotide
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.