Paper Details

  1. Home
  2. Paper Details

Pharmacokinetic Analysis, Analgesic Effects, and Adverse Effects of Tapentadol in Cancer Patients with Pain.

Author: AtsudaKoichiro, HayashiNorihito, HommaMasashi, KanaiAkifumi, KatadaChikatoshi, KoizumiWasaburo, KokubunHideya, OkuwakiKosuke

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Tapentadol (TP) is an opioid with sufficient analgesic effects for cancer patients. However, clearance of TP was significantly reduced in patients with impaired liver function, suggesting the need for dose adjustments in these patients.
Paper Details　
Original Abstract of the Article :
In this study, we conducted a pharmacokinetic analysis of tapentadol (TP) in Japanese patients with cancer pain and identified covariates influencing pharmacokinetic parameters. In addition, the analgesic effects and adverse effects of TP were investigated. Data were collected from in-patients with ...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://doi.org/10.1248/bpb.b20-00084

データ提供：米国国立医学図書館（NLM）

Tapentadol: A New Hope for Cancer Pain

Cancer pain is a debilitating symptom that can significantly impact quality of life. This study explores the pharmacokinetics, analgesic effects, and adverse effects of tapentadol, an opioid analgesic, in patients with cancer pain.

Tapentadol: Effective Pain Relief with Minimal Side Effects

The study found that tapentadol effectively reduced pain intensity in patients with cancer pain, a promising finding for individuals struggling with this challenging symptom. The researchers observed that tapentadol's clearance was influenced by liver function, emphasizing the importance of careful dose adjustments based on individual liver health.

Managing Cancer Pain: Finding the Right Balance

This research highlights the importance of finding the right balance between pain relief and potential side effects when managing cancer pain. Tapentadol, with its favorable analgesic effects and manageable side effect profile, represents a potentially valuable option for patients seeking effective pain relief.

Dr. Camel's Conclusion

This study sheds light on the efficacy and safety of tapentadol for cancer pain, offering hope for a better quality of life for patients facing this challenging symptom. The research underscores the importance of individualized treatment plans based on each patient's unique needs and health status.

Date :
  1. Date Completed 2021-01-21
  2. Date Revised 2021-01-21
Further Info :

Pubmed ID

32475909

DOI: Digital Object Identifier

10.1248/bpb.b20-00084

Related Literature

Article Analysis
・Effects of tapentadol
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.