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Sodium glucose cotransporter 2 inhibitors as diuretic adjuvants in acute decompensated heart failure: a case series.

Author: CollinsSean, FlemingJames, GriffinMatthew, InzucchiSilvio E, Ivey-MirandaJuan, MaulionChristopher, McCallumWendy, RaoVeena S, RielloRalph, SarnakMark, TestaniJeffrey M

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.

Overview

SGLT-2i's are being explored as potential loop diuretic adjuvants in acute decompensated heart failure, given their demonstrated heart failure benefits and potential diuretic effects.
Paper Details　
Original Abstract of the Article :
Diuretic resistance is common in acute decompensated heart failure (ADHF). When loop diuretic monotherapy is ineffective, thiazides are often recommended as adjunctive therapy, but these agents have many side effects and are associated with worsened survival. In contrast, sodium glucose cotransporte...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7373933/

データ提供：米国国立医学図書館（NLM）

Diuretic Resistance in Heart Failure: A New Oasis in the Desert?

This case series explores the potential of sodium glucose cotransporter 2 inhibitors (SGLT-2i's), initially developed for type 2 diabetes, as adjunctive therapy for diuretic resistance in acute decompensated heart failure (ADHF).

This case series is noteworthy for its exploration of a novel treatment approach for a challenging clinical situation.

SGLT-2i's as Adjunctive Therapy for Diuretic Resistance

The researchers describe the safety and efficacy of SGLT-2i's as loop diuretic adjuvants in ADHF, highlighting their potential for improving fluid management and reducing symptoms of heart failure. This approach could offer a promising alternative to traditional thiazide diuretics, which often have significant side effects.

Navigating Heart Failure Treatment: Dr. Camel's Thoughts

Managing heart failure is like traversing a vast desert, requiring careful attention to fluid balance and medication management. This case series offers a glimmer of hope for individuals struggling with diuretic resistance, suggesting a potential new avenue for improving heart failure outcomes.

Dr.Camel's Conclusion

This case series, like a shimmering mirage in the desert of heart failure research, suggests a potential new role for SGLT-2i's in managing diuretic resistance. While further research is needed, the findings provide hope for improved treatment options for individuals with ADHF.

Date :
  1. Date Completed 2021-06-21
  2. Date Revised 2021-09-19
Further Info :

Pubmed ID

32476296

DOI: Digital Object Identifier

PMC7373933

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