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In vivo analysis of the effects of intravenously as well as orally administered moxifloxacin on the pharmacokinetic and electrocardiographic variables along with its torsadogenic action in the chronic atrioventricular block cynomolgus monkeys.
Author: ChibaKoki, GotoAi, Hagiwara-NagasawaMihoko, Izumi-NakasekoHiroko, KambayashiRyuichi, MatsumotoAkio, NunoiYoshio, SakamotoKengo, SugiyamaAtsushi, TakeiYoshinori
Original Abstract of the Article :
We analyzed the effects of intravenously as well as orally administered moxifloxacin on the pharmacokinetic and electrocardiographic variables along with its torsadogenic action using the chronic atrioventricular block cynomolgus monkeys with a cross-over design. Initially, moxifloxacin was intraven...See full text at original site
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ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。
* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
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* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。
引用元:
https://doi.org/10.1016/j.jphs.2020.05.006
データ提供:米国国立医学図書館(NLM)
Moxifloxacin: A Careful Journey Through the Desert of Cardiac Repolarization
The [use of medications] can sometimes lead to [unintended consequences], particularly for those with [cardiac conditions]. This study investigates the [effects of moxifloxacin] on [pharmacokinetic and electrocardiographic variables] and its [potential for torsadogenic action] in [cynomolgus monkeys with chronic atrioventricular block]. The authors found that [high doses of moxifloxacin, particularly intravenously, increased the risk of torsade de pointes], a [potentially life-threatening arrhythmia].
Moxifloxacin: A Careful Approach for Cardiac Patients
This study highlights the [potential risks] of [moxifloxacin] in [patients with pre-existing cardiac conditions]. The authors emphasize the need for [careful monitoring] and [dose adjustment] to minimize the [risk of torsade de pointes].
Navigating the Desert of Cardiac Medications: Considerations for Patients
If you have [cardiac conditions] and are considering [moxifloxacin], it is essential to [discuss the potential risks] with your doctor. [Open communication] and [close monitoring] are essential for [safe and effective treatment].
Dr.Camel's Conclusion
The desert of cardiac medications can be a dangerous place for those with pre-existing conditions. This study reminds us of the importance of [understanding the potential risks] of [medications] and [making informed decisions] about our health.
Date :
- Date Completed 2020-08-10
- Date Revised 2020-08-10
Further Info :
Related Literature
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