In vivo analysis of the effects of intravenously as well as orally administered moxifloxacin on the pharmacokinetic and electrocardiographic variables along with its torsadogenic action in the chronic atrioventricular block cynomolgus monkeys.

Author: ChibaKoki, GotoAi, Hagiwara-NagasawaMihoko, Izumi-NakasekoHiroko, KambayashiRyuichi, MatsumotoAkio, NunoiYoshio, SakamotoKengo, SugiyamaAtsushi, TakeiYoshinori

Paper Details 
Original Abstract of the Article :
We analyzed the effects of intravenously as well as orally administered moxifloxacin on the pharmacokinetic and electrocardiographic variables along with its torsadogenic action using the chronic atrioventricular block cynomolgus monkeys with a cross-over design. Initially, moxifloxacin was intraven...See full text at original site
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引用元:
https://doi.org/10.1016/j.jphs.2020.05.006

データ提供:米国国立医学図書館(NLM)

Moxifloxacin: A Careful Journey Through the Desert of Cardiac Repolarization

The [use of medications] can sometimes lead to [unintended consequences], particularly for those with [cardiac conditions]. This study investigates the [effects of moxifloxacin] on [pharmacokinetic and electrocardiographic variables] and its [potential for torsadogenic action] in [cynomolgus monkeys with chronic atrioventricular block]. The authors found that [high doses of moxifloxacin, particularly intravenously, increased the risk of torsade de pointes], a [potentially life-threatening arrhythmia].

Moxifloxacin: A Careful Approach for Cardiac Patients

This study highlights the [potential risks] of [moxifloxacin] in [patients with pre-existing cardiac conditions]. The authors emphasize the need for [careful monitoring] and [dose adjustment] to minimize the [risk of torsade de pointes].

Navigating the Desert of Cardiac Medications: Considerations for Patients

If you have [cardiac conditions] and are considering [moxifloxacin], it is essential to [discuss the potential risks] with your doctor. [Open communication] and [close monitoring] are essential for [safe and effective treatment].

Dr.Camel's Conclusion

The desert of cardiac medications can be a dangerous place for those with pre-existing conditions. This study reminds us of the importance of [understanding the potential risks] of [medications] and [making informed decisions] about our health.

Date :
  1. Date Completed 2020-08-10
  2. Date Revised 2020-08-10
Further Info :

Pubmed ID

32499095

DOI: Digital Object Identifier

10.1016/j.jphs.2020.05.006

Related Literature

SNS
PICO Info
in preparation
Languages

English

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