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Aromatase Inhibitors Plus Weight Loss Improves the Hormonal Profile of Obese Hypogonadal Men Without Causing Major Side Effects.

Author: Armamento-VillarealReina, ChenRui, ColleluoriGeorgia, JohnsonBiju, MediwalaSanjay, QuallsClifford, TurinChristie G, VigevanoFrancesca, VillarealDennis T

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Aromatase inhibitor plus weight loss therapy improved the hormonal profile of hypogonadotropic hypogonadism in obese men but did not lead to significant improvements in muscle strength or symptoms compared to weight loss alone. While the therapy resulted in higher fat mass loss and did not have major side effects, it led to a minimal increase in total and LDL cholesterol and a decrease in tibial trabecular bone area.
Paper Details　
Original Abstract of the Article :
<b>Objective:</b> In obese men, the increased expression of the aromatase enzyme in adipose tissue leads to high conversion of androgens to estrogens contributing to hypogonadotropic hypogonadism (HHG). Our objective is to evaluate efficacy and safety of weight loss (WL) plus aromatase inhibitor (A...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7243137/

データ提供：米国国立医学図書館（NLM）

Aromatase Inhibitors and Weight Loss: A Potential Solution for Hypogonadal Men

Obesity can lead to hormonal imbalances, particularly in men, causing [hypogonadotropic hypogonadism (HHG)]. This study explores the effectiveness of [aromatase inhibitors (AIs) combined with weight loss] in treating HHG. The authors found that this approach significantly improved the [hormonal profile] of obese men with HHG. This is a promising finding, offering a potential avenue for addressing the hormonal challenges associated with obesity.

Reversing Hormonal Imbalances: A Balancing Act

The study demonstrates that combining [AI treatment with weight loss] can effectively restore hormonal balance in obese men. This is like re-establishing the delicate balance of a desert ecosystem, where each element plays a crucial role in maintaining harmony. The findings suggest that targeting both weight and hormone levels could lead to better management of HHG.

Maintaining Health and Well-being

While the study shows positive results in terms of [hormonal profile], it also highlights the importance of considering [potential side effects] associated with AI treatment. It is essential to weigh the benefits and risks, just as a traveler would carefully consider the potential hazards of a long journey across the desert.

Dr. Camel's Conclusion

This study offers valuable insights into the potential of AI and weight loss in treating HHG in obese men. While further research is needed to fully understand the long-term implications, the study suggests that this approach could be a promising treatment option for men struggling with HHG.
Date :
  1. Date Completed 2021-05-19
  2. Date Revised 2021-05-19
Further Info :

Pubmed ID

32499757

DOI: Digital Object Identifier

PMC7243137

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Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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