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Teriparatide Promotes Bone Healing in Medication-Related Osteonecrosis of the Jaw: A Placebo-Controlled, Randomized Trial.

Author: BorromeoGelsomina L, CookGary J R, EbelingPeter R, HardimanRita, HofmanMichael S, Papatziamos HjelleChristian, SeymourJohn F, SiddiqueMusib, SimIe-Wen, TsaoClaudine

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Medication-related osteonecrosis of the jaw (MRONJ) is a rare but serious problem that can happen with certain medications. While good oral hygiene can help prevent MRONJ, treating it once it happens is difficult. Teriparatide, a medication that strengthens bones, has shown promise in studies, potentially offering a new treatment option.
Paper Details　
Original Abstract of the Article :
Medication-related osteonecrosis of the jaw (MRONJ) is an infrequent but morbid and potentially serious condition associated with antiresorptive and antiangiogenic therapies. Although MRONJ can be prevented by optimizing oral health, management of established cases is supportive and remains challeng...See full text at original site
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引用元：
https://doi.org/10.1200/JCO.19.02192

データ提供：米国国立医学図書館（NLM）

Teriparatide: A Potential Oasis in the Desert of Medication-Related Osteonecrosis of the Jaw

The field of [dentistry] is constantly searching for effective treatments for medication-related osteonecrosis of the jaw (MRONJ), a serious complication associated with antiresorptive and antiangiogenic therapies. This study investigates the potential of teriparatide, an osteoanabolic agent, as a treatment option for MRONJ. The authors highlight the challenges of managing established cases of MRONJ and the need for new therapeutic approaches. They present a placebo-controlled, randomized trial that evaluated the effects of teriparatide on bone healing in patients with MRONJ. Based on preclinical studies and the agent's efficacy in chronic periodontitis, the researchers hypothesized that teriparatide could promote bone healing in MRONJ.

Teriparatide: A Promising Beacon in the Fight Against MRONJ

This study suggests that teriparatide holds promise as a treatment for MRONJ. The results of the randomized trial provide encouraging evidence that teriparatide promotes bone healing in patients with this challenging condition. These findings offer a glimmer of hope for individuals struggling with MRONJ and emphasize the importance of exploring new therapeutic options.

Navigating the Challenges of MRONJ: A Camel's Perspective

MRONJ can be a daunting and debilitating condition. This research offers a potential oasis in the desert of MRONJ management. Teriparatide presents a promising avenue for promoting bone healing and improving the quality of life for patients. By embracing new treatment approaches and continuing research, we can pave the way for better outcomes for individuals facing this challenging condition.

Dr. Camel's Conclusion

This study explores a potential oasis in the desert of MRONJ management. Just as a camel relies on oases to survive, individuals struggling with MRONJ may find hope in the potential of teriparatide. This research encourages continued exploration of new therapeutic options and the pursuit of better outcomes for patients facing this challenging condition.

Date :
  1. Date Completed 2021-02-24
  2. Date Revised 2021-07-12
Further Info :

Pubmed ID

32614699

DOI: Digital Object Identifier

10.1200/JCO.19.02192

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・Effective treatment of osteonecrosis
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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