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Long-term outcomes of patients with ulcerative proctitis: Analysis from a large referral centre cohort.

Author: DuboisEvelyne, FerranteMarc, GeelenRob, MoensAnnick, SabinoJoão, VermeireSéverine

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Ulcerative proctitis (UP) showed good clinical outcomes, with treatment success in 87% of patients. However, 28% required escalation to biological therapy, and long-term outcomes were superior for patients on biological therapy compared to azathioprine.
Paper Details　
Original Abstract of the Article :
INTRODUCTION: Long-term outcomes of patients with ulcerative proctitis (UP) have been poorly investigated, since these patients are excluded from participation in randomized controlled clinical trials. OBJECTIVE: The aim of this study was to investigate the prognostic and therapeutic long-term outc...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7707867/

データ提供：米国国立医学図書館（NLM）

Long-Term Outcomes of Patients with Ulcerative Proctitis

This study delves into the long-term outcomes of patients with ulcerative proctitis (UP), a form of inflammatory bowel disease that primarily affects the rectum. The research examines the effectiveness of different treatment strategies for UP, particularly those who are refractory to standard therapies. The study's findings reveal that a significant proportion of patients with UP experience long-term remission, but a subset require escalation to more aggressive treatments, including biological therapies.

Biological Therapies: A Potential Solution for Refractory UP

The study's findings demonstrate the efficacy of biological therapies in achieving long-term remission in patients with refractory UP. This highlights the critical role of these treatments in managing complex and challenging cases of inflammatory bowel disease. The research also underscores the importance of individualized treatment approaches, tailoring therapies to meet the unique needs of each patient.

Navigating the Desert of Inflammatory Bowel Disease

Inflammatory bowel disease (IBD) is a complex and often unpredictable condition, requiring a nuanced and personalized approach to management. This research provides valuable insights into the long-term outcomes of patients with UP, particularly those who are refractory to standard therapies. The study's findings highlight the potential of biological therapies in achieving long-term remission, offering hope for patients facing challenging IBD symptoms. The study serves as a compass, guiding clinicians towards more effective and personalized strategies for managing IBD.

Dr.Camel's Conclusion

This study sheds light on the long-term outcomes of patients with ulcerative proctitis, emphasizing the importance of individualized treatment approaches and the potential benefits of biological therapies for refractory cases. As we journey through the vast desert of IBD research, this study serves as a vital oasis, offering insights into the complexities of this disease and the potential for achieving long-term remission.
Date :
  1. Date Completed 2021-07-12
  2. Date Revised 2021-07-12
Further Info :

Pubmed ID

32631177

DOI: Digital Object Identifier

PMC7707867

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Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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