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Precision medicine and its implementation in patients with NTRK fusion genes: perspective from developing countries.

Author: ArrietaOscar, BarrónFeliciano, CardonaAndrés F, KarachaliouNiki, Molina-VilaMiguel Angel, RaezLuis, RicaurteLuisa, RojasLeonardo, RolfoChristian, RosellRafael, Ruiz-PatiñoAlejandro, SoteloCarolina, Zamudio-MolanoNataly, Zatarain-BarrónZyanya Lucia, ÁlvarezMarco Polo Peralta

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Overview

This review explores the promise of precision oncology in treating NTRK-positive tumors, regardless of histology or age group. The review highlights the approval of larotrectinib, the first drug approved based on molecular pattern rather than histology, and its significant results in disease control with good tolerability across a wide range of diseases. The review also discusses the potential of precision oncology to reduce cancer-related disability and hospital costs in developing nations.
Paper Details　
Original Abstract of the Article :
Precision oncology is the field that places emphasis on the diagnosis and treatment of tumors that harbor specific genomic alterations susceptible to inhibition or modulation. Although most alterations are only present in a minority of patients, a substantial effect on survival can be observed in th...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7350048/

データ提供：米国国立医学図書館（NLM）

Precision Medicine: A New Oasis in the Desert of Cancer Treatment

The fight against cancer is a relentless journey, seeking innovative strategies to target and defeat this complex disease. This study delves into the emerging field of precision oncology, focusing on the role of NTRK gene fusions in identifying patients who may benefit from targeted therapies. It highlights the potential of precision medicine to transform cancer treatment, particularly in developing countries.

A Targeted Approach to Cancer Therapy

The study emphasizes the importance of identifying specific genomic alterations, such as NTRK gene fusions, which can guide the selection of targeted therapies. It highlights the success of larotrectinib, a drug specifically designed to inhibit NTRK-positive tumors, demonstrating the effectiveness of this personalized approach. This research underscores the potential of precision medicine to significantly improve cancer outcomes, particularly for individuals with rare tumors.

Bridging the Gap: Extending Precision Medicine to Developing Countries

This study emphasizes the importance of extending the benefits of precision medicine to developing countries, which often face limited resources and access to advanced treatments. By embracing precision oncology, these countries can potentially improve cancer care, reducing the burden of disease and improving quality of life for their citizens. This research highlights the power of collaboration and innovation, offering hope for a brighter future in the global fight against cancer.

Dr.Camel's Conclusion

This study, like a refreshing spring in the midst of a vast desert, showcases the potential of precision medicine to transform cancer treatment, particularly in resource-limited settings. By embracing this personalized approach, we can bring the healing power of targeted therapies to a broader population, offering hope for a healthier future for all.

Date :
  1. Date Completed 2021-09-15
  2. Date Revised 2023-11-03
Further Info :

Pubmed ID

32643553

DOI: Digital Object Identifier

PMC7350048

Related Literature

Article Analysis
・Effects of larotrectinib
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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