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Dimerization-induced self-assembly of a redox-responsive prodrug into nanoparticles for improved therapeutic index.

Author: ChenDong, ChenXiaona, HanYaxuan, QiaoYiting, WanJianqin, WangHangxiang, XieHaiyang, XuShengjun, ZhengShusen, ZhouLin, ZhouLiqian

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study presents a novel strategy for converting a toxic drug, cabazitaxel, into a safe and effective nanomedicine. The strategy involves self-assembly of cabazitaxel dimers into nanoparticles, followed by PEGylation for systemic delivery. The resulting nanoparticles demonstrated a favorable safety profile in mice, with reduced systemic toxicity and negligible immunotoxicity. In two mouse xenograft models, the nanoparticles exhibited efficient antitumor activity with durable tumor suppression, highlighting the potential of this approach for developing clinically useful nanomedicines.
Paper Details　
Original Abstract of the Article :
Although some formats of nanomedicines are now available for clinical use, the translation of new nanoparticles to the clinic remains a considerable challenge. Here, we describe a simple yet cost-effective strategy that converts a toxic drug, cabazitaxel, into a safe and effective nanomedicine. The ...See full text at original site
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引用元：
https://doi.org/10.1016/j.actbio.2020.07.007

データ提供：米国国立医学図書館（NLM）

Nanomedicine: A New Approach for Drug Delivery

This research presents a novel strategy for converting a toxic drug, cabazitaxel, into a safe and effective nanomedicine. The study utilizes a self-assembling approach, ligating drug molecules via a self-immolating spacer and then dimerizing them to form stable nanoparticles. These nanoparticles, termed SNPs, exhibit improved safety and therapeutic efficacy compared to free cabazitaxel. The study utilizes a combination of chemical synthesis, nanotechnology, and preclinical animal models to develop and evaluate the SNPs, demonstrating their potential as a safe and effective drug delivery platform.

SNPs: A Promising Advancement in Nanomedicine

The study's findings demonstrate the potential of this novel approach for developing safe and effective nanomedicines, highlighting the advantages of self-assembly and bioactivatable linkers in drug delivery. The research offers hope for developing innovative nanomedicines that can overcome the limitations of traditional drug delivery methods.

Nanomedicine: A New Frontier in Drug Delivery

This research exemplifies the exciting potential of nanotechnology in drug delivery, paving the way for safer and more effective treatment options. Think of it like navigating a desert with a new and reliable guide – nanomedicine can help us navigate the complexities of drug delivery and achieve more favorable outcomes.

Dr.Camel's Conclusion

This research explores a novel approach to drug delivery using self-assembling nanoparticles, offering potential for safer and more effective treatment options. Think of it like a desert traveler discovering a new and reliable oasis – nanomedicine holds promise for improving the delivery and effectiveness of drugs, transforming how we treat disease.

Date :
  1. Date Completed 2021-05-14
  2. Date Revised 2021-05-14
Further Info :

Pubmed ID

32652227

DOI: Digital Object Identifier

10.1016/j.actbio.2020.07.007

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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