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S-adenosyl-L-methionine (SAMe) halts the autoimmune response in patients with primary biliary cholangitis (PBC) via antioxidant and S-glutathionylation processes in cholangiocytes.

Author: AvilaM A, BanalesJ M, BarbierO, KilanczykE, MatoJ M, MilkiewiczM, MilkiewiczP, WunschE

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study investigated the potential therapeutic value of S-adenosyl-L-methionine (SAMe) in patients with primary biliary cholangitis (PBC), an autoimmune disease affecting the liver. SAMe was found to improve liver biochemistry and reduce anti-mitochondrial autoantibodies in a subset of patients. The study also showed that SAMe has antioxidant properties and can protect liver cells from damage. These findings suggest that SAMe may have a therapeutic role in PBC.
Paper Details　
Original Abstract of the Article :
S-adenosyl-L-methionine is an endogenous molecule with hepato-protective properties linked to redox regulation and methylation. Here, the potential therapeutic value of SAMe was tested in 17 patients with PBC, a cholestatic disease with autoimmune phenomena targeting small bile ducts. Nine patients ...See full text at original site
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引用元：
https://doi.org/10.1016/j.bbadis.2020.165895

データ提供：米国国立医学図書館（NLM）

S-adenosyl-L-methionine (SAMe): A Potential Oasis in the Desert of Primary Biliary Cholangitis (PBC)

The human body is a complex ecosystem, and autoimmune diseases, like PBC, can be like experiencing a harsh desert environment. This study explores the potential benefits of SAMe, a naturally occurring molecule, as a treatment for PBC, a chronic liver disease that affects the bile ducts. The researchers found that SAMe could halt the autoimmune response in PBC patients, potentially offering a much-needed oasis of relief. Their findings suggest that SAMe's effectiveness may stem from its antioxidant and S-glutathionylation properties, which could help restore balance within the liver.

A New Hope for Primary Biliary Cholangitis: SAMe's Potential for Healing

This research offers a glimmer of hope for individuals living with PBC. SAMe's potential to halt the autoimmune response could be a significant breakthrough in managing this complex and challenging condition. It's like discovering a hidden oasis in the desert, offering a source of healing and improved quality of life for those affected by PBC. It's a reminder that even in the face of seemingly insurmountable challenges, there is always hope for new discoveries and better treatments.

A Journey Towards a Healthier Liver: Embracing the Potential of SAMe

This research provides a compelling argument for further investigation into the therapeutic potential of SAMe for PBC. It's like embarking on a journey through the desert, seeking a path to a healthier liver. By understanding the mechanisms of SAMe's action and its potential benefits, we can explore new treatment options and offer greater hope to individuals struggling with this challenging condition.

Dr.Camel's Conclusion

This research represents a promising development in the field of liver disease, offering a potential oasis of relief for those suffering from PBC. SAMe's ability to halt the autoimmune response and its potential to improve liver function provides a glimmer of hope for a better future. By further exploring the potential of SAMe, we can continue our journey towards a world where liver diseases are better understood and treated.

Date :
  1. Date Completed 2020-12-08
  2. Date Revised 2020-12-14
Further Info :

Pubmed ID

32681864

DOI: Digital Object Identifier

10.1016/j.bbadis.2020.165895

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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