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The high incidence of severe adverse events due to pyrazinamide in elderly patients with tuberculosis.

Author: ChoYoung-Jae, KimYoulim, KwonByoung Soo, LeeChoon-Taek, LeeJae Ho, LeeSang Hoon, LeeYeon Joo, LimSung Yoon, ParkJong Sun, YoonHo Il

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Pyrazinamide (PZA) was the most common drug associated with serious adverse events (SAEs) among first-line anti-tuberculosis drugs. Older age was an independent risk factor for SAEs.
Paper Details　
Original Abstract of the Article :
BACKGROUND: Pyrazinamide (PZA) is a common drug that causes serious adverse events (SAEs). The aim of this study was to determine the incidence of and risk factors for SAEs due to PZA during first-line anti-tuberculosis treatment. METHODS: The medical records of patients with tuberculosis (TB) trea...See full text at original site
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難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7373258/

データ提供：米国国立医学図書館（NLM）

Pyrazinamide: A Potential Pitfall in Tuberculosis Treatment

This study focuses on the [adverse events] associated with [pyrazinamide (PZA)], a common drug used in [tuberculosis (TB)] treatment. Researchers analyzed medical records of 2,478 patients with TB who received PZA-containing regimens to determine the incidence and risk factors for [serious adverse events (SAEs)] due to PZA. Their findings reveal that PZA is the most frequent culprit for SAEs, particularly in elderly patients. The study emphasizes the need for careful monitoring and appropriate interventions to mitigate the potential risks associated with PZA use in TB treatment.

Understanding the Risks of Pyrazinamide

The study highlights the significant risk of SAEs, particularly hepatotoxicity and gastrointestinal intolerance, associated with PZA use in elderly TB patients. This underscores the importance of close monitoring for these adverse effects and timely intervention to prevent complications.

Safeguarding Patient Well-Being

This research serves as a reminder that even essential medications like PZA can have potentially serious side effects. It emphasizes the need for vigilant monitoring of patients receiving PZA, particularly those at higher risk. Early detection and appropriate management of SAEs are crucial for ensuring patient safety and optimizing treatment outcomes.

Dr.Camel's Conclusion

This study highlights the need for a cautious approach to TB treatment, particularly in elderly patients. Just as a camel must navigate treacherous desert landscapes, healthcare providers must be alert to the potential risks and navigate carefully to ensure patient safety and well-being.
Date :
  1. Date Completed 2020-09-17
  2. Date Revised 2020-09-17
Further Info :

Pubmed ID

32692774

DOI: Digital Object Identifier

PMC7373258

Related Literature

Article Analysis
・Side Effects of pyrazinamide
SNS
PICO Info
in preparation
Languages

English

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