Paper Details 
Original Abstract of the Article :
Urgent need for treatments limit studies of therapeutic drugs before approval by regulatory agencies. Analyses of drugs after approval can therefore improve our understanding of their mechanism of action and enable better therapies. We screened a library of 1443 Food and Drug Administration (FDA)-ap...See full text at original site
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引用元:
https://pubmed.ncbi.nlm.nih.gov/32731027

データ提供:米国国立医学図書館(NLM)

The Hidden Desert of Drug Effects: Unveiling Morphological Changes in C. elegans

Imagine a vast desert landscape where the effects of drugs are hidden beneath the surface. This research explores the potential for unexpected effects of FDA-approved drugs by using the powerful model organism, *C. elegans*. Think of *C. elegans* as a tiny desert explorer, revealing hidden secrets beneath the sands of drug interactions. The researchers screened a library of FDA-approved drugs for their effects on *C. elegans* morphology, uncovering three compounds that caused distinct morphological changes. These findings highlight the importance of continued research into the potential effects of drugs, even after they have been approved for use.

Unveiling the Desert's Secrets

The study discovered that ticlopidine, sertaconazole, and dexlansoprazole, all FDA-approved drugs, led to significant morphological changes in *C. elegans*. These findings suggest that even drugs with established safety profiles can have unexpected effects, underscoring the need for continued research into their long-term implications. This research serves as a reminder that the desert of drug effects is vast and complex, requiring ongoing exploration to ensure the safety and well-being of patients.

Exploring the Desert Landscape

This research highlights the importance of using model organisms like *C. elegans* to explore the hidden landscape of drug effects. The study's findings emphasize the need for continued research into the potential implications of drugs, even after they have been approved for use. By exploring this vast desert landscape, we can gain a deeper understanding of drug interactions and ensure the safety and well-being of those who rely on these medications.

Dr.Camel's Conclusion

The desert of drug effects is vast and complex. This research, using *C. elegans* as a desert explorer, reveals unexpected morphological changes caused by FDA-approved drugs. This underscores the importance of continued research to unveil the hidden secrets of drug interactions, ensuring the safety and effectiveness of these medications.

Date :
  1. Date Completed 2020-11-05
  2. Date Revised 2021-12-03
Further Info :

Pubmed ID

32731027

DOI: Digital Object Identifier

NIHMS1615229

Related Literature

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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