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Effects of glucagon-like peptide-1 receptor agonists liraglutide and semaglutide on cardiovascular and renal outcomes across body mass index categories in type 2 diabetes: Results of the LEADER and SUSTAIN 6 trials.

Author: BainStephen C, BhattDeepak L, BuseJohn B, LeiterLawrence A, MazerC David, McGuireDarren K, Monk FriesTea, PratleyRichard E, RasmussenSøren, VermaSubodh, VrazicHrvoje, ZinmanBernard

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Liraglutide and semaglutide, both GLP-1 RAs, were found to be beneficial for patients with type 2 diabetes and high risk of cardiovascular events regardless of their baseline BMI. While some heterogeneity was observed in the SUSTAIN 6 trial, further studies are needed to confirm these findings.
Paper Details　
Original Abstract of the Article :
Associations between body mass index (BMI) and the cardiovascular (CV) and kidney efficacy of glucagon-like peptide-1 receptor agonists (GLP-1 RAs) in patients with type 2 diabetes (T2D) are uncertain; therefore, data analysed separately from the Liraglutide Effect and Action in Diabetes: Evaluation...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7754406/

データ提供：米国国立医学図書館（NLM）

GLP-1 Receptor Agonists: A New Oasis in the Desert of Type 2 Diabetes

The desert of type 2 diabetes is vast and complex, with many challenges to overcome. This research focused on the potential of glucagon-like peptide-1 receptor agonists (GLP-1 RAs), like liraglutide and semaglutide, to address these challenges. The authors analyzed data from two large clinical trials, LEADER and SUSTAIN 6, investigating the cardiovascular and renal effects of GLP-1 RAs across different body mass index (BMI) categories. Their findings suggest that these drugs may offer significant benefits for patients with type 2 diabetes, regardless of their BMI. This discovery is like finding a precious oasis in the heart of the desert, offering relief and hope for those struggling with this chronic condition.

GLP-1 Receptor Agonists: A Promising Pathway for Diabetes Management

The study's findings suggest that GLP-1 RAs, like a refreshing spring in the desert, could play a vital role in managing type 2 diabetes. These drugs may help to improve cardiovascular and renal outcomes, potentially reducing the risk of complications associated with this condition. While further research is needed, the results offer a promising avenue for diabetes management, especially for those who are overweight or obese.

Staying Hydrated for Better Diabetes Management

Type 2 diabetes, like a relentless desert heat, requires constant vigilance and attention. Maintaining a healthy lifestyle, including a balanced diet and regular exercise, is crucial for managing this condition. Just as a traveler in the desert needs to stay hydrated, individuals with type 2 diabetes need to monitor their blood sugar levels and make lifestyle changes to ensure optimal health.

Dr.Camel's Conclusion

This study is a beacon of hope in the desert of type 2 diabetes. It underscores the potential of GLP-1 RAs in improving the lives of individuals with this challenging condition. Just as a desert traveler relies on a compass to navigate, we can look to scientific research to guide us towards better health and well-being.

Date :
  1. Date Completed 2021-06-24
  2. Date Revised 2021-06-29
Further Info :

Pubmed ID

32744418

DOI: Digital Object Identifier

PMC7754406

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Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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