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Engineering of Nanospheres Dispersed Microneedle System for Antihypertensive Action.

Author: SardesaiMrunmayi, ShendePravin

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

This study developed bio-responsive microneedles for the co-delivery of nifedipine and diltiazem in the treatment of hypertension. Diltiazem was encapsulated in pH-responsive PLGA nanospheres and incorporated into microneedles along with nifedipine. The microneedles demonstrated sustained release of nifedipine over 24 hours, while diltiazem was released upon contact with the acidic pH of the skin. The formulation significantly reduced mean blood pressure in a rat model compared to the disease control group. The system offers a potential alternative approach to conventional drug delivery systems for hypertension management.
Paper Details　
Original Abstract of the Article :
BACKGROUND: A combinational therapy is mostly preferred in hypertension treatment because of low-dose and less side effects like pretibial edema, and gastrointestinal bleeding. OBJECTIVE: So the objective of the present work was to formulate an advanced drug delivery system in the form of bio-respo...See full text at original site
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引用元：
https://doi.org/10.2174/1567201817666200804110003

データ提供：米国国立医学図書館（NLM）

Nanospheres Dispersed Microneedle System for Antihypertensive Action

This study explores the development of a novel drug delivery system for hypertension treatment. The researchers formulated pH-responsive PLGA nanospheres loaded with diltiazem, a vasodilator, and incorporated these nanospheres into microneedles containing nifedipine, a cardiodepressant. This innovative system aimed to achieve synergistic effects by co-delivering these two drugs for effective antihypertensive action. In preclinical studies, the microneedle system demonstrated controlled release of both drugs and achieved a significant reduction in blood pressure.

Microneedle System: A Promising Approach for Hypertension Treatment

This research presents a novel microneedle system for the co-delivery of nifedipine and diltiazem, offering a potentially effective approach for managing hypertension. The system's ability to achieve synergistic effects by combining these two drugs and its controlled release profile suggest a promising alternative to conventional drug delivery methods. However, further studies are required to evaluate its long-term efficacy and safety in human subjects.

Navigating the Desert of Hypertension

Think of hypertension as a harsh desert environment, where blood pressure can fluctuate and threaten health. This microneedle system, like a desert caravan carrying essential supplies, offers a potentially effective way to deliver the necessary medications for managing hypertension and maintaining a stable blood pressure.

Dr. Camel's Conclusion

This study presents a promising novel drug delivery system for hypertension treatment, utilizing microneedles to co-deliver nifedipine and diltiazem for synergistic antihypertensive action. The system's controlled release profile and positive preclinical results warrant further research to evaluate its long-term efficacy and safety in human subjects. This innovative approach offers a potential solution to the challenges of managing hypertension, potentially improving patient outcomes and enhancing cardiovascular health.
Date :
  1. Date Completed 2021-08-02
  2. Date Revised 2021-08-02
Further Info :

Pubmed ID

32753011

DOI: Digital Object Identifier

10.2174/1567201817666200804110003

Related Literature

Article Analysis
・Side Effects of diltiazem
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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