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Peripherally Acting μ-Opioid Receptor Antagonists in the Management of Postoperative Ileus: a Clinical Review.

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Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Overview

Postoperative ileus and constipation are common side effects of opioid pain medications. Peripherally acting μ-opioid receptor antagonists (PAMORAs) block the effects of opioids on the gut, but not on the brain, allowing them to relieve constipation without reducing pain relief. This review discusses recent clinical trials of PAMORAs, alvimopan and methylnaltrexone, in patients with postoperative ileus or constipation. More research is needed to better understand how these drugs work and how to use them effectively.
Paper Details　
Original Abstract of the Article :
Postoperative ileus (POI) and constipation are common secondary effects of opioids and carry significant clinical and economic impacts. μ-Opioid receptors mediate opioid analgesia in the central nervous system (CNS) and gastrointestinal-related effects in the periphery. Peripherally acting &#95...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7851096/

データ提供：米国国立医学図書館（NLM）

Peripherally Acting μ-Opioid Receptor Antagonists: A New Approach to Postoperative Ileus

Opioids are essential for pain management, but they often come with unwanted side effects. This research explores the potential of peripherally acting μ-opioid receptor antagonists (PAMORAs) in the management of postoperative ileus (POI) and opioid-induced constipation (OIC). PAMORAs selectively block the peripheral effects of opioids in the gastrointestinal tract while maintaining opioid analgesia in the central nervous system. This study reviews recent clinical trials evaluating the safety and efficacy of PAMORAs, with a focus on alvimopan and methylnaltrexone, in patients with POI and postoperative OIC.

PAMORAs: A Targeted Approach to Opioid-Related Side Effects

The review highlights the potential of PAMORAs for reducing the gastrointestinal side effects associated with opioids while preserving their analgesic benefits. The clinical trials reviewed in this study suggest that alvimopan and methylnaltrexone may be effective in treating POI and postoperative OIC.

A Shift in Opioid Management

This research suggests that PAMORAs may play a significant role in the future of opioid management, offering a targeted approach to addressing the gastrointestinal side effects of opioids. Further research is needed to optimize the use of PAMORAs and to explore their potential for managing other opioid-related side effects.

Dr.Camel's Conclusion

This review explores the potential of peripherally acting μ-opioid receptor antagonists (PAMORAs) for managing postoperative ileus and opioid-induced constipation. The review highlights the selective action of PAMORAs, blocking peripheral opioid effects while preserving central analgesic effects. The clinical trials reviewed suggest that alvimopan and methylnaltrexone may be effective in treating these conditions. This research offers a promising avenue for improving the management of opioid-related gastrointestinal side effects.

Date :
  1. Date Completed 2021-04-19
  2. Date Revised 2021-04-19
Further Info :

Pubmed ID

32779081

DOI: Digital Object Identifier

PMC7851096

Related Literature

Article Analysis
・Effects of alvimopan
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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