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Management of Chemotherapy-Induced Nausea and Vomiting (CINV): A Short Review on the Role of Netupitant-Palonosetron (NEPA).

Author: CodegaPaolo, GiottaFrancesco, LorussoVito, RussoAnna

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Overview

NEPA, a fixed combination antiemetic containing the 5HT3 receptor antagonist palonosetron and the NK1 receptor antagonist netupitant, is used to prevent chemotherapy-induced nausea and vomiting.
Paper Details　
Original Abstract of the Article :
Antineoplastic drugs may induce several side effects, including chemotherapy-induced nausea and vomiting (CINV). Two neurotransmitters play a central role in mediating the emetic response: serotonin acting on the 5HT3 receptor and the substance P targeting the NK1 receptor. Indeed, a combination of ...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7394513/

データ提供：米国国立医学図書館（NLM）

Managing Chemotherapy-Induced Nausea and Vomiting (CINV)

This study reviews the role of netupitant-palonosetron (NEPA) in managing chemotherapy-induced nausea and vomiting (CINV), a common side effect of cancer treatment. The research highlights the importance of targeting both serotonin and substance P pathways to effectively prevent CINV. The study discusses the advantages of NEPA, a fixed combination antiemetic that combines a 5HT3 receptor antagonist and a NK1 receptor antagonist, offering a promising approach to managing CINV.

Improving the Quality of Life for Cancer Patients

The study emphasizes the importance of managing CINV to improve the quality of life for cancer patients. The research highlights the potential benefits of NEPA, a drug that can effectively prevent nausea and vomiting, reducing the burden of this distressing side effect. The study's findings offer hope for improved patient comfort and well-being during cancer treatment.

Advancing Cancer Care

The study highlights the advancements in cancer care, focusing on strategies to manage the side effects of chemotherapy. The research emphasizes the importance of developing effective antiemetics to improve the quality of life for cancer patients.

Dr.Camel's Conclusion

This study, like a cool oasis offering respite from the desert heat, explores the role of NEPA in managing CINV. The research provides valuable insights into improving patient comfort and well-being during cancer treatment, offering hope for a more tolerable and effective cancer care experience.

Date :
  1. Date Completed n.d.
  2. Date Revised 2022-04-16
Further Info :

Pubmed ID

32802009

DOI: Digital Object Identifier

PMC7394513

Related Literature

Article Analysis
・Effects of netupitant and palonosetron
SNS
PICO Info
in preparation
Languages

English

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