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Intranasal lipid nanocapsules for systemic delivery of nimodipine into the brain: In vitro optimization and in vivo pharmacokinetic study.

Author: AllamNageh K, AzzazyHassan M E, BasaliousEmad B, MohsenKarim

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

This study explored the potential of intranasal lipid nanocapsules (LNCs) for delivering nimodipine (NM) to the brain. NM LNCs were found to deliver the same amount of NM to brain tissue as IV administration but with lower drug levels in blood, minimizing cardiovascular side effects.
Paper Details　
Original Abstract of the Article :
Nimodipine (NM) is FDA-approved drug for treating subarachnoid haemorrhage induced vasospasm. Intravenous (IV) administration, the most common route of NM, causes several side effects such as hypotension, bradycardia, arrhythmias and inflammation at site of administration. The aim of this study was ...See full text at original site
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引用元：
https://doi.org/10.1016/j.msec.2020.111236

データ提供：米国国立医学図書館（NLM）

Intranasal Lipid Nanocapsules: A New Delivery System for Nimodipine

This study investigates the potential of intranasal lipid nanocapsules (LNCs) as a novel delivery system for nimodipine, a drug used to treat vasospasm following subarachnoid hemorrhage. The study explores the feasibility of using LNCs to deliver nimodipine directly to the brain, potentially reducing side effects associated with intravenous administration.

Intranasal Delivery: A Targeted Approach

The study demonstrates the successful development of optimized LNCs that effectively deliver nimodipine to the brain following intranasal administration. The intranasal route offers a targeted approach for delivering drugs to the brain, minimizing systemic exposure and reducing the risk of side effects.

Improving Drug Delivery: Enhanced Therapy

This study offers a promising new strategy for delivering nimodipine to the brain, potentially improving treatment outcomes and reducing the incidence of adverse effects. Further research is needed to evaluate the clinical efficacy and safety of this novel delivery system.

Dr.Camel's Conclusion

Just as a camel navigates the desert with remarkable efficiency, this study explores new ways to navigate the complex landscape of drug delivery. The development of intranasal LNCs offers a potential solution for delivering drugs directly to the brain, minimizing systemic side effects and potentially improving patient outcomes. This research is a camel's stride forward in the quest for more effective and targeted therapies.

Date :
  1. Date Completed 2021-05-14
  2. Date Revised 2021-05-14
Further Info :

Pubmed ID

32806316

DOI: Digital Object Identifier

10.1016/j.msec.2020.111236

Related Literature

Article Analysis
・Side Effects of nimodipine
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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