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Drug-Drug Interactions between Direct Oral Anticoagulants and Hepatitis C Direct-Acting Antiviral Agents: Looking for Evidence Through a Systematic Review.

Author: BellesiniMarta, BianchinMatteo, CorradiChiara, DonadiniMarco Paolo, RaschiEmanuel, SquizzatoAlessandro

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Overview

This systematic review examined drug-drug interactions (DDIs) between direct oral anticoagulants (DOACs) and hepatitis C direct-acting antiviral agents (DAAs). The authors highlight the potential for DAAs to increase DOAC exposure and bleeding risk.
Paper Details　
Original Abstract of the Article :
Direct oral anticoagulants (DOACs), as substrates of cytochrome P450 (CYP) 3A4 and/or P-glycoprotein, are susceptible to drug-drug interactions (DDIs). Hepatitis C direct-acting antiviral agents (DAAs), via P-glycoprotein or CYP3A4 inhibition, may increase DOAC exposure with relevant bleeding risk. ...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7595962/

データ提供：米国国立医学図書館（NLM）

Drug Interactions Between Direct Oral Anticoagulants and Hepatitis C Direct-Acting Antiviral Agents

This systematic review examines potential drug-drug interactions (DDIs) between direct oral anticoagulants (DOACs) and hepatitis C direct-acting antiviral agents (DAAs). Both DOACs and DAAs are metabolized by enzymes that can lead to interactions, potentially increasing DOAC exposure and bleeding risk. The researchers conducted a systematic review to gather evidence on these DDIs.

Navigating the Complex World of Drug Interactions

This review underscores the importance of understanding potential drug interactions, particularly when treating patients with both DOACs and DAAs. The study highlights the need for careful monitoring and dose adjustments to ensure patient safety and optimize therapeutic outcomes.

Prioritizing Patient Safety

Drug interactions can have significant implications for patient health. This study emphasizes the importance of close collaboration between healthcare providers and pharmacists to identify and manage potential DDIs. It also encourages patients to be proactive in communicating their medication history and any concerns they may have.

Dr.Camel's Conclusion

The world of drug interactions can be as vast and intricate as a desert landscape. This review serves as a valuable guide, helping us navigate the complexities of drug interactions and prioritize patient safety. It reminds us that careful planning and communication are crucial for optimal treatment outcomes.
Date :
  1. Date Completed 2020-12-22
  2. Date Revised 2021-01-20
Further Info :

Pubmed ID

32809123

DOI: Digital Object Identifier

PMC7595962

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Languages

English

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