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The metabolic effects of mirabegron are mediated primarily by &#946;<sub>3</sub> -adrenoceptors.

Author: BengtssonTore, BokhariMuhammad Hamza, ChiaLing Yeong, DehvariNodi, EvansBronwyn A, GaoJie, HamSeungmin, HutchinsonDana S, KalinovichAnastasia, MerlinJon, MukaidaSaori, NguyenHuong T M, SatoMasaaki, SummersRoger J, WhitingLynda, WoottenDenise

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study investigated the effect of the β3-adrenoceptor agonist mirabegron on glucose homeostasis in vitro and in vivo. Mirabegron was found to improve glucose handling in vivo, primarily through actions at the β3-adrenoceptor.
Paper Details　
Original Abstract of the Article :
The &#946;<sub>3</sub> -adrenoceptor agonist mirabegron is approved for use for overactive bladder and has been purported to be useful in the treatment of obesity-related metabolic diseases in humans, including those involving disturbances of glucose homeostasis. We investigated the effect of mirabe...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7437350/

データ提供：米国国立医学図書館（NLM）

The Metabolic Effects of Mirabegron Are Mediated Primarily by β3-Adrenoceptors

This study explores the metabolic effects of mirabegron, a medication primarily used for treating overactive bladder. The authors meticulously investigated the mechanism of mirabegron's action, uncovering its key role in regulating glucose homeostasis. The study specifically focuses on the role of β3-adrenoceptors in mediating mirabegron's metabolic effects.

Mirabegron: Beyond Overactive Bladder

The study suggests that mirabegron's therapeutic potential extends beyond the treatment of overactive bladder, potentially offering benefits for managing obesity-related metabolic diseases. The research delves into the intricate mechanisms by which mirabegron interacts with β3-adrenoceptors, ultimately influencing glucose metabolism.

Unlocking the Potential of Mirabegron

This study represents a significant step forward in understanding the potential of mirabegron for managing metabolic disorders. The research highlights the importance of targeted therapies that engage specific receptors, like β3-adrenoceptors, to achieve desired metabolic outcomes.

Dr. Camel's Conclusion

This study uncovers the intriguing metabolic effects of mirabegron, suggesting that this medication, commonly used for overactive bladder, might hold promise for managing obesity-related metabolic diseases. The research highlights the critical role of β3-adrenoceptors in mediating mirabegron's metabolic effects, opening up new avenues for exploring its potential therapeutic applications.
Date :
  1. Date Completed 2021-06-29
  2. Date Revised 2021-06-29
Further Info :

Pubmed ID

32813332

DOI: Digital Object Identifier

PMC7437350

Related Literature

Article Analysis
・Effects of mirabegron
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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