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Sarecycline interferes with tRNA accommodation and tethers mRNA to the 70S ribosome.

Author: BatoolZahra, BunickChristopher G, LomakinIvan B, PolikanovYury S

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, U.S. Gov't, Non-P.H.S.Research funding provided by US government agencies other than the Public Health Service.

Overview

This study determined the X-ray crystal structure of sarecycline bound to the Thermus thermophilus 70S ribosome. The structure reveals that sarecycline binds at the canonical tetracycline binding site and that its unique C7 extension interacts with the mRNA channel, potentially interfering with mRNA movement and/or codon-anticodon interaction.
Paper Details　
Original Abstract of the Article :
Sarecycline is a new narrow-spectrum tetracycline-class antibiotic approved for the treatment of acne vulgaris. Tetracyclines share a common four-ring naphthacene core and inhibit protein synthesis by interacting with the 70S bacterial ribosome. Sarecycline is distinguished chemically from other tet...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7456112/

データ提供：米国国立医学図書館（NLM）

Sarecycline: A New Oasis in the Desert of Bacterial Infections

Imagine a fierce desert battleground, where bacteria wage war against the human body. This study delves into the mechanism of action of sarecycline, a new antibiotic specifically targeting acne vulgaris. Sarecycline, like a cunning desert warrior, disrupts the bacterial machinery, effectively halting protein synthesis and preventing bacterial growth. The study explores the unique structure of sarecycline and its interaction with the bacterial ribosome, providing insights into its potent antimicrobial activity.

A New Weapon in the Desert: Sarecycline's Unique Mechanism

This study unveils the unique mechanism of action of sarecycline, highlighting its ability to target the bacterial ribosome and effectively inhibit protein synthesis. This new understanding of sarecycline's potency and specificity offers a promising approach for combating specific bacterial infections.

Navigating the Desert of Antibiotics: Using Antibiotics Wisely

Antibiotics are powerful tools for fighting bacterial infections but should be used responsibly to prevent antibiotic resistance. It is crucial to consult a healthcare professional for appropriate diagnosis and treatment, ensuring effective and safe use of antibiotics.

Dr.Camel's Conclusion

This study highlights the promising potential of sarecycline, a new weapon in the desert of bacterial infections. By understanding its unique mechanism of action and targeting the bacterial ribosome, this antibiotic offers a powerful strategy for combating acne vulgaris and potentially other bacterial infections.

Date :
  1. Date Completed 2020-10-22
  2. Date Revised 2021-09-19
Further Info :

Pubmed ID

32817463

DOI: Digital Object Identifier

PMC7456112

Related Literature

Article Analysis
・Effects of sarecycline
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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